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• W2566748320 endingPage "61" @default.
• W2566748320 startingPage "42" @default.
• W2566748320 abstract "Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly clustered regularly interspaced short palindromic repeats (CRISPR)—will allow us to improve our understanding of genomic variation in disease processes via cellular and animal models. Here, we highlight the progress made in correcting gene mutations in monogenic hereditary disorders and discuss various CRISPR-associated applications, such as cancer research, synthetic biology, and gene therapy using induced pluripotent stem cells. The challenges, ethical issues, and future prospects of CRISPR-based systems for human research are also discussed." @default.
• W2566748320 created "2017-01-06" @default.
• W2566748320 creator A5011861620 @default.
• W2566748320 creator A5029524189 @default.
• W2566748320 creator A5067646394 @default.
• W2566748320 date "2017-01-01" @default.
• W2566748320 modified "2023-09-25" @default.
• W2566748320 title "CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells" @default.
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