Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566839077> ?p ?o ?g. }
- W2566839077 endingPage "195" @default.
- W2566839077 startingPage "187" @default.
- W2566839077 abstract "Introduction: The beneficial effects of glucocorticoids are highly regarded in the treatment of inflammatory diseases. In rheumatoid arthritis, these drugs are widely used because they effectively reduce signs and symptoms of the disease, and exert disease-modifying effects. However, both patients and physicians frequently associate glucocorticoids with a variety of adverse effects which hamper adherence. Due to this ambivalent nature of these drugs, several new glucocorticoids or glucocorticoid receptor ligands are being developed, aiming at improving their benefit-risk balance.Areas covered: Focussing on rheumatoid arthritis, we discuss current approaches to achieve this goal, including an optimized application of conventional glucocorticoids and the development of novel formulations aiming at minimizing adverse effects while keeping or even enhancing the anti-inflammatory efficacy.Expert opinion: Glucocorticoids – be it conventional or modified/delayed-release formulations – have so far been convincing in clinical practice, and their widespread use will therefore continue. They are not likely to be replaced by novel drugs in the near future although some investigational preparations are promising, and results obtained from currently ongoing clinical trials in humans are eagerly awaited. As a result of these developmental activities, a further improvement of the benefits-risk balance of glucocorticoids or glucocorticoid receptor ligands is expected." @default.
- W2566839077 created "2017-01-06" @default.
- W2566839077 creator A5003759876 @default.
- W2566839077 creator A5008286981 @default.
- W2566839077 creator A5058094909 @default.
- W2566839077 creator A5063928355 @default.
- W2566839077 creator A5082434195 @default.
- W2566839077 date "2017-01-03" @default.
- W2566839077 modified "2023-10-14" @default.
- W2566839077 title "Glucocorticoid-targeted therapies for the treatment of rheumatoid arthritis" @default.
- W2566839077 cites W1506897495 @default.
- W2566839077 cites W1524223037 @default.
- W2566839077 cites W1845063635 @default.
- W2566839077 cites W1930073633 @default.
- W2566839077 cites W1965978465 @default.
- W2566839077 cites W1968436319 @default.
- W2566839077 cites W1987741121 @default.
- W2566839077 cites W1994286426 @default.
- W2566839077 cites W1994321363 @default.
- W2566839077 cites W1994955363 @default.
- W2566839077 cites W1996429452 @default.
- W2566839077 cites W1997103341 @default.
- W2566839077 cites W1997510672 @default.
- W2566839077 cites W2001141315 @default.
- W2566839077 cites W2003194886 @default.
- W2566839077 cites W2008600516 @default.
- W2566839077 cites W2027015272 @default.
- W2566839077 cites W2032407781 @default.
- W2566839077 cites W2037939754 @default.
- W2566839077 cites W2038623197 @default.
- W2566839077 cites W2043703663 @default.
- W2566839077 cites W2046267631 @default.
- W2566839077 cites W2047008569 @default.
- W2566839077 cites W2049928087 @default.
- W2566839077 cites W2051715499 @default.
- W2566839077 cites W2054115898 @default.
- W2566839077 cites W2060862416 @default.
- W2566839077 cites W2060990402 @default.
- W2566839077 cites W2063838991 @default.
- W2566839077 cites W2067181732 @default.
- W2566839077 cites W2073611489 @default.
- W2566839077 cites W2075994714 @default.
- W2566839077 cites W2076226743 @default.
- W2566839077 cites W2081203345 @default.
- W2566839077 cites W2083719502 @default.
- W2566839077 cites W2085944780 @default.
- W2566839077 cites W2086238123 @default.
- W2566839077 cites W2086871852 @default.
- W2566839077 cites W2093627967 @default.
- W2566839077 cites W2098903427 @default.
- W2566839077 cites W2099866582 @default.
- W2566839077 cites W2106471110 @default.
- W2566839077 cites W2108134938 @default.
- W2566839077 cites W2110114520 @default.
- W2566839077 cites W2111357501 @default.
- W2566839077 cites W211424878 @default.
- W2566839077 cites W2119761908 @default.
- W2566839077 cites W2121133349 @default.
- W2566839077 cites W2128447685 @default.
- W2566839077 cites W2134766532 @default.
- W2566839077 cites W2136255927 @default.
- W2566839077 cites W2137953708 @default.
- W2566839077 cites W2141109451 @default.
- W2566839077 cites W2141406354 @default.
- W2566839077 cites W2144376792 @default.
- W2566839077 cites W2145390209 @default.
- W2566839077 cites W2148231159 @default.
- W2566839077 cites W2148239961 @default.
- W2566839077 cites W2149841789 @default.
- W2566839077 cites W2151337536 @default.
- W2566839077 cites W2154610519 @default.
- W2566839077 cites W2155195115 @default.
- W2566839077 cites W2155536923 @default.
- W2566839077 cites W2156849645 @default.
- W2566839077 cites W2160740929 @default.
- W2566839077 cites W2161580101 @default.
- W2566839077 cites W2168089399 @default.
- W2566839077 cites W2168200807 @default.
- W2566839077 cites W2171682550 @default.
- W2566839077 cites W2172062119 @default.
- W2566839077 cites W2174133343 @default.
- W2566839077 cites W2292748966 @default.
- W2566839077 cites W2293561363 @default.
- W2566839077 cites W2293589736 @default.
- W2566839077 cites W2312776009 @default.
- W2566839077 cites W2319800350 @default.
- W2566839077 cites W2326509045 @default.
- W2566839077 cites W2335436766 @default.
- W2566839077 cites W2345882020 @default.
- W2566839077 cites W2381801185 @default.
- W2566839077 cites W2506855355 @default.
- W2566839077 cites W4210768724 @default.
- W2566839077 cites W4229597922 @default.
- W2566839077 cites W4294350876 @default.
- W2566839077 cites W835961366 @default.
- W2566839077 doi "https://doi.org/10.1080/13543784.2017.1276562" @default.
- W2566839077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28043173" @default.
- W2566839077 hasPublicationYear "2017" @default.