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- W2566883371 abstract "To understand the mechanism underlying bone marrow metastasis in breast cancer, we have established a highly bone marrow metastatic mouse breast cancer cell line, 4T1E/M3. While metastatic potential of 4T1E/M3 to bone was quite high (about 80%) when injected intravenously to mice, it was rather low (about 20%) when injected subcutaneously. Then using 4T1E/M3 cells, we carried out the in vitro and in vivo selection and established higher bone marrow metastatic cells, FP10SC2, which have a very high potential of metastases to lungs (100%) and spines (85%) when subcutaneously injected to mice. DNA microarray analysis revealed that the gene expression of cadherin17 was upregulated in FP10SC2 compared to the parental 4T1E/M3. When the expression of cadherin17 was suppressed by RNAi, the anchorage independent growth and migration activity was dramatically decreased. Moreover, metastatic activity of cadherin17(-)/FP10SC2 to spines was significantly reduced compared to control/FP10SC2. When cadherin 17 was overexpressed in 4T1E/M3 parental cells, the colony formation and migration activity was clearly augmented. Taken together, it was suggested that cadherin 17 plays an important role on breast cancer metastasis to bone marrow. Citation Format: Tomoko Okada, Mutsuo Furihata, Atsushi Kurabayashi, Toru Imamura. Cadherin 17 plays an important role in breast cancer metastasis to bone marrow. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2253. doi:10.1158/1538-7445.AM2015-2253" @default.
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- W2566883371 date "2015-08-01" @default.
- W2566883371 modified "2023-09-27" @default.
- W2566883371 title "Abstract 2253: Cadherin 17 plays an important role in breast cancer metastasis to bone marrow" @default.
- W2566883371 doi "https://doi.org/10.1158/1538-7445.am2015-2253" @default.
- W2566883371 hasPublicationYear "2015" @default.
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