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- W2566984513 abstract "Experimental, chronic Schistosoma infections protect against allergic airway inflammation (AAI), in which splenic, IL-10 producing regulatory B (Breg) cells play a prominent role. Interestingly, we found that pulmonary B cells could also protect against ovalbumin-induced AAI. So far, we excluded a role for IL-10, secreted antibodies or Treg cell-induction by schistosome-induced pulmonary B cells in the observed effect. Phenotypic characterisation revealed a strong up-regulation of the low-affinity IgE receptor CD23, and to a lesser extent of the co-stimulatory molecule CD86, while they produced less cytokines in response to TLR ligands. Co-cultures of naive, OVA-transgenic T cells with OVA-pulsed pulmonary B cells from S. mansoni-infected, allergic mice resulted in a reduced production of the type-2 cytokines IL-4, IL-13 and IL-10 compared to non-infected, allergic controls. This reduction in Th2 cytokine production could not be overcome by a polyclonal stimulation with anti-CD3/28 in co-cultures with naive T cells from wild-type mice. This observation suggests that pulmonary B cells from infected animals are impaired in their capacity to induce Th2 cells regardless of their capacity to present antigens and/or to provide co-stimulation. Until now, blocking of IL-6, IL-10, TGF-β, or CTLA-4 in B cell-T cell co-cultures did not result in a full restoration of Th2 cytokine production. To further study the features of helminth-induced pulmonary B cells, we are currently investigating their gene expression profile by microarray technology. Altogether, these data show that pulmonary B cells protect against AAI and directly modulate T cell-cytokine production." @default.
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- W2566984513 date "2015-09-01" @default.
- W2566984513 modified "2023-09-25" @default.
- W2566984513 title "Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function" @default.
- W2566984513 doi "https://doi.org/10.1183/13993003.congress-2015.pa1895" @default.
- W2566984513 hasPublicationYear "2015" @default.
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