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• W2566996822 startingPage "373" @default.
• W2566996822 abstract "We have developed doxorubicin (DOX)-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles (DP) conjugated with polyethylene glycol (PEG) and transferrin (Tf) to form Tf-PEG-DPs (TPDPs), and incorporated these TPDPs into three-dimensional (3-D) PLGA porous scaffolds to form a controlled delivery system. To our knowledge, this represents the first use of a Tf variant (oxalate Tf) to improve the targeted delivery of drug-encapsulated nanoparticles (NPs) in PLGA scaffolds to PC3 prostate cancer cells. The PLGA scaffolds with TPDPs incorporated have been shown to release drugs for sustained delivery and provided a continuous release of DOX. The MTS assay was also performed to determine the potency of native and oxalate TPDPs, and a 3.0-fold decrease in IC50 values were observed between the native and oxalate TPDPs. The lower IC50 value for the oxalate version signifies greater potency compared to the native version, since a lower concentration of drug was required to achieve the same therapeutic effect. These results suggest that this technology has potential to become a new implantable polymeric device to improve the controlled and targeted drug delivery of Tf-conjugated NPs for cancer therapy." @default.
• W2566996822 created "2017-01-06" @default.
• W2566996822 creator A5001971105 @default.
• W2566996822 creator A5003276906 @default.
• W2566996822 creator A5090130231 @default.
• W2566996822 date "2017-04-01" @default.
• W2566996822 modified "2023-10-16" @default.
• W2566996822 title "A transferrin variant as the targeting ligand for polymeric nanoparticles incorporated in 3-D PLGA porous scaffolds" @default.
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• W2566996822 doi "https://doi.org/10.1016/j.msec.2016.12.091" @default.
• W2566996822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28183621" @default.
• W2566996822 hasPublicationYear "2017" @default.
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