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- W2567058507 abstract "In mammals, the circadian timing system drives rhythms of physiology and behaviour, including the daily rhythms of feeding and activity. The timing system coordinates temporal variation in the biochemical landscape with changes in nutrient intake in order to optimise energy balance and maintain metabolic homeostasis. Circadian disruption (e.g. as a result of shift work or jet lag) can disturb this continuity and increase the risk of cardiometabolic disease. Obesity and metabolic disease can also disturb the timing and amplitude of the clock in multiple organ systems, further exacerbating disease progression. As our understanding of the synergy between the timing system and metabolism has grown, an interest has emerged in the development of novel clock-targeting pharmaceuticals or nutraceuticals for the treatment of metabolic dysfunction. Recently, the pineal hormone melatonin has received some attention as a potential chronotherapeutic drug for metabolic disease. Melatonin is well known for its sleep-promoting effects and putative activity as a chronobiotic drug, stimulating coordination of biochemical oscillations through targeting the internal timing system. Melatonin affects the insulin secretory activity of the pancreatic beta cell, hepatic glucose metabolism and insulin sensitivity. Individuals with type 2 diabetes mellitus have lower night-time serum melatonin levels and increased risk of comorbid sleep disturbances compared with healthy individuals. Further, reduced melatonin levels, and mutations and/or genetic polymorphisms of the melatonin receptors are associated with an increased risk of developing type 2 diabetes. Herein we review our understanding of molecular clock control of glucose homeostasis, detail the influence of circadian disruption on glucose metabolism in critical peripheral tissues, explore the contribution of melatonin signalling to the aetiology of type 2 diabetes, and discuss the pros and cons of melatonin chronopharmacotherapy in disease management." @default.
- W2567058507 created "2017-01-06" @default.
- W2567058507 creator A5005698298 @default.
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- W2567058507 creator A5023876856 @default.
- W2567058507 creator A5035672164 @default.
- W2567058507 creator A5073660418 @default.
- W2567058507 date "2016-12-16" @default.
- W2567058507 modified "2023-10-17" @default.
- W2567058507 title "Chronomedicine and type 2 diabetes: shining some light on melatonin" @default.
- W2567058507 cites W1484240941 @default.
- W2567058507 cites W1484892115 @default.
- W2567058507 cites W1505050831 @default.
- W2567058507 cites W1542348680 @default.
- W2567058507 cites W1543971242 @default.
- W2567058507 cites W1596570309 @default.
- W2567058507 cites W1622386501 @default.
- W2567058507 cites W1760538771 @default.
- W2567058507 cites W1787893252 @default.
- W2567058507 cites W1823075735 @default.
- W2567058507 cites W1830081267 @default.
- W2567058507 cites W1888131842 @default.
- W2567058507 cites W1901438300 @default.
- W2567058507 cites W1935468480 @default.
- W2567058507 cites W1965397317 @default.
- W2567058507 cites W1966891298 @default.
- W2567058507 cites W1973259490 @default.
- W2567058507 cites W1979226119 @default.
- W2567058507 cites W1980202250 @default.
- W2567058507 cites W1981495544 @default.
- W2567058507 cites W1982209205 @default.
- W2567058507 cites W1982216464 @default.
- W2567058507 cites W1982974848 @default.
- W2567058507 cites W1983398904 @default.
- W2567058507 cites W1985945913 @default.
- W2567058507 cites W1986608768 @default.
- W2567058507 cites W1987546711 @default.
- W2567058507 cites W1989620158 @default.
- W2567058507 cites W1990356462 @default.
- W2567058507 cites W1992320749 @default.
- W2567058507 cites W1997151200 @default.
- W2567058507 cites W1997463511 @default.
- W2567058507 cites W1998320088 @default.
- W2567058507 cites W2001564098 @default.
- W2567058507 cites W2002425527 @default.
- W2567058507 cites W2005693445 @default.
- W2567058507 cites W2007247773 @default.
- W2567058507 cites W2008560948 @default.
- W2567058507 cites W2008596767 @default.
- W2567058507 cites W2009377263 @default.
- W2567058507 cites W2013233045 @default.
- W2567058507 cites W2013252791 @default.
- W2567058507 cites W2013360705 @default.
- W2567058507 cites W2014069918 @default.
- W2567058507 cites W2014234042 @default.
- W2567058507 cites W2014422314 @default.
- W2567058507 cites W2014780202 @default.
- W2567058507 cites W2015114583 @default.
- W2567058507 cites W2015685907 @default.
- W2567058507 cites W2020343018 @default.
- W2567058507 cites W2021032705 @default.
- W2567058507 cites W2021474976 @default.
- W2567058507 cites W2022220021 @default.
- W2567058507 cites W2022531681 @default.
- W2567058507 cites W2022873602 @default.
- W2567058507 cites W2027098051 @default.
- W2567058507 cites W2029785742 @default.
- W2567058507 cites W2035143857 @default.
- W2567058507 cites W2039398849 @default.
- W2567058507 cites W2039517931 @default.
- W2567058507 cites W2041347130 @default.
- W2567058507 cites W2041979789 @default.
- W2567058507 cites W2042185382 @default.
- W2567058507 cites W2043197814 @default.
- W2567058507 cites W2046319626 @default.
- W2567058507 cites W2046820969 @default.
- W2567058507 cites W2047034018 @default.
- W2567058507 cites W2051075072 @default.
- W2567058507 cites W2052162699 @default.
- W2567058507 cites W2056265088 @default.
- W2567058507 cites W2060035520 @default.
- W2567058507 cites W2061017853 @default.
- W2567058507 cites W2062360005 @default.
- W2567058507 cites W2063946784 @default.
- W2567058507 cites W2064348721 @default.
- W2567058507 cites W2066199795 @default.
- W2567058507 cites W2069943416 @default.
- W2567058507 cites W2070753981 @default.
- W2567058507 cites W2071469400 @default.
- W2567058507 cites W2073747041 @default.
- W2567058507 cites W2076778900 @default.
- W2567058507 cites W2078689239 @default.
- W2567058507 cites W2080096829 @default.
- W2567058507 cites W2080926694 @default.
- W2567058507 cites W2081139788 @default.
- W2567058507 cites W2081996218 @default.
- W2567058507 cites W2082209905 @default.
- W2567058507 cites W2082407123 @default.