Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567060343> ?p ?o ?g. }
- W2567060343 endingPage "e0168015" @default.
- W2567060343 startingPage "e0168015" @default.
- W2567060343 abstract "In our research, we explored the relationship between Keratin 26 and the regulation of fine hair, BMP signaling pathway, MT, FGF5, and IGF-I. The result of hybridization in situ revealed that Keratin 26 was specially expressed in cortex of skin hair follicles; the result of immunohistochemistry indicated that Keratin 26 was expressed in internal root sheath, external root sheath. Then, Real-time quantitative PCR results showed that relative expressive quantity of Keratin 26 was 1.08 or 3.3 × greater in secondary follicle than primary follicle during anagen or catagen; the difference during anagen was not remarkable (p>0.05), however, that of catagen was extremely significant (p<0.01). Relative expressive quantity of Keratin 26 increased during telogen; the difference was extremely significant (p<0.01). Moreover, after Noggin expression interference using RNAi technology, we found that relative expressive quantity of Keratin 26 extremely remarkably declined (p<0.01); after K26 overexpression, we found that relative expressive quantity of Noggin extremely remarkably increased (p<0.01). We detected expressive quantity change of Keratin 26 and Keratin 26 using Real-time quantitative PCR and immunofluorescence technologies after fibroblasts were treated with MT, FGF5 or IGF-I; the results indicated that MT and FGF5 played a positive role in Keratin 26 and Keratin 26 expression, IGF-I played a negative role in Keratin 26 expression, positive role in Keratin 26 expression. The results above showed that Keratin 26 could inhibit cashmere growth, and was related to entering to catagen and telogen of hair follicles; Keratin 26 and BMP signaling pathway were two antagonistic pathways each other which could inhibit growth and development of cashmere; MT, FGF5 and IGF-I could affect expression of Keratin 26 and Keratin 26, and Keratin 26 was one of the important pathways that MT induced cashmere production in advance, FGF5 regulated cashmere growth and IGF-I promoted cashmere growth and development." @default.
- W2567060343 created "2017-01-06" @default.
- W2567060343 creator A5016400342 @default.
- W2567060343 creator A5035134259 @default.
- W2567060343 creator A5037677450 @default.
- W2567060343 creator A5041011240 @default.
- W2567060343 creator A5044407910 @default.
- W2567060343 creator A5050677069 @default.
- W2567060343 date "2016-12-20" @default.
- W2567060343 modified "2023-09-25" @default.
- W2567060343 title "The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family" @default.
- W2567060343 cites W112612438 @default.
- W2567060343 cites W1496872610 @default.
- W2567060343 cites W1532399084 @default.
- W2567060343 cites W1970010964 @default.
- W2567060343 cites W1971468831 @default.
- W2567060343 cites W1975721378 @default.
- W2567060343 cites W1976584345 @default.
- W2567060343 cites W1983816227 @default.
- W2567060343 cites W1984288177 @default.
- W2567060343 cites W1987468551 @default.
- W2567060343 cites W1994979888 @default.
- W2567060343 cites W1996340200 @default.
- W2567060343 cites W1996371854 @default.
- W2567060343 cites W2002154018 @default.
- W2567060343 cites W2015545654 @default.
- W2567060343 cites W2021804892 @default.
- W2567060343 cites W2024962684 @default.
- W2567060343 cites W2028605253 @default.
- W2567060343 cites W2033287794 @default.
- W2567060343 cites W2042462751 @default.
- W2567060343 cites W2042522786 @default.
- W2567060343 cites W2047652196 @default.
- W2567060343 cites W2052786526 @default.
- W2567060343 cites W2056016311 @default.
- W2567060343 cites W2058687436 @default.
- W2567060343 cites W2060661631 @default.
- W2567060343 cites W2063390793 @default.
- W2567060343 cites W2067149192 @default.
- W2567060343 cites W2067388223 @default.
- W2567060343 cites W2069199400 @default.
- W2567060343 cites W2077661650 @default.
- W2567060343 cites W2081736574 @default.
- W2567060343 cites W2089334702 @default.
- W2567060343 cites W2094468743 @default.
- W2567060343 cites W2094919417 @default.
- W2567060343 cites W2104852357 @default.
- W2567060343 cites W2108308082 @default.
- W2567060343 cites W2111630067 @default.
- W2567060343 cites W2116587859 @default.
- W2567060343 cites W2117914733 @default.
- W2567060343 cites W2124479860 @default.
- W2567060343 cites W2125373960 @default.
- W2567060343 cites W2127631125 @default.
- W2567060343 cites W2134938413 @default.
- W2567060343 cites W2136344605 @default.
- W2567060343 cites W2142851541 @default.
- W2567060343 cites W2145032231 @default.
- W2567060343 cites W2156183359 @default.
- W2567060343 cites W2171997622 @default.
- W2567060343 cites W2433705893 @default.
- W2567060343 cites W55042985 @default.
- W2567060343 doi "https://doi.org/10.1371/journal.pone.0168015" @default.
- W2567060343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5173340" @default.
- W2567060343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27997570" @default.
- W2567060343 hasPublicationYear "2016" @default.
- W2567060343 type Work @default.
- W2567060343 sameAs 2567060343 @default.
- W2567060343 citedByCount "13" @default.
- W2567060343 countsByYear W25670603432018 @default.
- W2567060343 countsByYear W25670603432019 @default.
- W2567060343 countsByYear W25670603432020 @default.
- W2567060343 countsByYear W25670603432021 @default.
- W2567060343 countsByYear W25670603432022 @default.
- W2567060343 crossrefType "journal-article" @default.
- W2567060343 hasAuthorship W2567060343A5016400342 @default.
- W2567060343 hasAuthorship W2567060343A5035134259 @default.
- W2567060343 hasAuthorship W2567060343A5037677450 @default.
- W2567060343 hasAuthorship W2567060343A5041011240 @default.
- W2567060343 hasAuthorship W2567060343A5044407910 @default.
- W2567060343 hasAuthorship W2567060343A5050677069 @default.
- W2567060343 hasBestOaLocation W25670603431 @default.
- W2567060343 hasConcept C104317684 @default.
- W2567060343 hasConcept C108335385 @default.
- W2567060343 hasConcept C142669718 @default.
- W2567060343 hasConcept C1491633281 @default.
- W2567060343 hasConcept C150194340 @default.
- W2567060343 hasConcept C153911025 @default.
- W2567060343 hasConcept C170178370 @default.
- W2567060343 hasConcept C189689871 @default.
- W2567060343 hasConcept C203014093 @default.
- W2567060343 hasConcept C204232928 @default.
- W2567060343 hasConcept C2777216303 @default.
- W2567060343 hasConcept C2778761762 @default.
- W2567060343 hasConcept C2779012181 @default.
- W2567060343 hasConcept C2780668125 @default.
- W2567060343 hasConcept C31507581 @default.
- W2567060343 hasConcept C50548948 @default.