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- W256706687 abstract "Abstract : Thalamic innervation of cortex is a complex process in which specific regions of the thalamus must grow into precise cortical regions. Once within a specific cortical area, thalamic aflerents terminate largely upon a target population of cortical cells. within the somatosensory cortex, thalamic afferents terminate largely upon layer 4 cells. To further understand the importance of layer 4 in shaping the development of thalamic afferents and the specificity of their connectivity within somatosensory cortex, we disrupted the formation of layer 4 of ferret somatosensory cortex using the anti-mitotic drug, methylazoxy methanol acetate (MAM) on embryonic day 33 (E33). As a control, MAM was administered to a second group of animals on E3S to interfere with layer 2 fornation. Following MAM treatment, two sets of experiments were performed. In the first set of experiments, small crystals of the lipiphilic tracer, Dil were placed into the ventral basal (vB) region of thalamus of fixed brains obtained at Pi, P7 and P14. The distribution of thalamic fibers within the somatosensory" @default.
- W256706687 created "2016-06-24" @default.
- W256706687 creator A5057482153 @default.
- W256706687 date "1999-07-03" @default.
- W256706687 modified "2023-09-27" @default.
- W256706687 title "The Role of Layer 4 in Thalamocortical Development" @default.
- W256706687 doi "https://doi.org/10.21236/ad1012172" @default.
- W256706687 hasPublicationYear "1999" @default.
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