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- W2567148861 abstract "Background: Spirometry before and after bronchodilator (BD) is performed to assess airflow limitation (AL) reversibility. In patients with normal baseline spirometry the frequency of a positive and paradoxical bronchodilator response, has not been well described. Aim: To assess the frequency of a positive and paradoxical response in adults with normal baseline spirometry as well as with an AL. Methods: The RESearch on the PrEvalence and the diagnosis of chronic obstructive pulmonary disease (COPD) and its Tobacco-related aetiology (RESPECT) is a prospective, population-based cohort study in adults 35-70 years old in North-West Russia. Spirometry before and after BD was performed and AL measured by a ratio of FEV1/FVC Results: 3133 individuals met the inclusion criteria; 2974 and 2388 of those demonstrated satisfactory quality on spirometry before- and after BD test, respectively. 31.8% of the study population was male and 47.8% had ever smoked. Almost 3% of those without AL by both cut-offs had a positive response to BD and almost 1% of the participants with normal pre-BD FEV1/FVC by both cut-offs converted to AL after the BD. The prevalence of reversible AL was 1.3% (95% CI 0.9 – 1.9) for fixed cut-off and 1.1% (95% CI 0.7 – 1.6) for LLN suggesting that these participants may have an asthma-COPD overlap syndrome (ACOS). Conclusion: Spirometry with BD is required for a comprehensive COPD and ACOS diagnosis as well as for detection of latent positive bronchodilator response for patients without AL." @default.
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- W2567148861 date "2015-09-01" @default.
- W2567148861 modified "2023-09-25" @default.
- W2567148861 title "Bronchodilator response in adults 35-70 years old in North-West Russia" @default.
- W2567148861 doi "https://doi.org/10.1183/13993003.congress-2015.pa1040" @default.
- W2567148861 hasPublicationYear "2015" @default.
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