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• W2567152128 startingPage "2902" @default.
• W2567152128 abstract "<ns4:p>Chordomas are rare primary bone tumors arising from embryonic remnants of the notochord. They are slow-growing, locally aggressive, and destructive and typically involve the axial skeleton. Genetic studies have identified several mutations implicated in the pathogenesis of these tumors. Treatment poses a challenge given their insidious progression, degree of local invasion at presentation, and high recurrence rate. They tend to respond poorly to conventional chemotherapy and radiation. This makes radical resection the mainstay of their treatment. Recent advances in targeted chemotherapy and focused particle beam radiation, however, have improved the management and prognosis of these tumors.</ns4:p>" @default.
• W2567152128 created "2017-01-06" @default.
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• W2567152128 creator A5036111853 @default.
• W2567152128 date "2016-12-22" @default.
• W2567152128 modified "2023-09-27" @default.
• W2567152128 title "Recent advances in understanding and managing chordomas" @default.
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• W2567152128 doi "https://doi.org/10.12688/f1000research.9499.1" @default.
• W2567152128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5224689" @default.
• W2567152128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28105324" @default.
• W2567152128 hasPublicationYear "2016" @default.
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