FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567161010> ?p ?o ?g. }

• W2567161010 abstract "Hyperuricemia is not only the main feature of gout but also a cause of gout-related organ injuries including glomerular hypertrophy and sclerosis. Uric acid (UA) has been proven to directly cause mesangial cell (MC) proliferation with elusive mechanisms. The present study was undertaken to examined the role of inflammatory cascade of COX-2/mPGES-1/PGE2 in UA-induced MC proliferation. In the dose- and time-dependent experiments, UA increased cell proliferation shown by the increased total cell number, DNA synthesis rate, and the number of cells in S and G2 phases in parallel with the upregulation of cyclin A2 and cyclin D1. Interestingly, UA-induced cell proliferation was accompanied with the upregulation of COX-2 and mPGES-1 at both mRNA and protein levels. Strikingly, inhibition of COX-2 via a specific COX-2 inhibitor NS-398 markedly blocked UA-induced MC proliferation. Meanwhile, UA-induced PGE2 production was almost entirely abolished. Furthermore, inhibiting mPGES-1 by a siRNA approach in MCs also ameliorated UA-induced MC proliferation in line with a significant blockade of PGE2 secretion. More importantly, in gout patients, we observed a significant elevation of urinary PGE2 excretion compared with healthy controls, indicating a translational potential of this study to the clinic. In conclusion, our findings indicated that COX-2/mPGES-1/PGE2 cascade activation mediated UA-induced MC proliferation. This study offered new insights into the understanding and the intervention of UA-related glomerular injury." @default.
• W2567161010 created "2017-01-06" @default.
• W2567161010 creator A5006572085 @default.
• W2567161010 creator A5007641864 @default.
• W2567161010 creator A5010776860 @default.
• W2567161010 creator A5023713376 @default.
• W2567161010 creator A5025319461 @default.
• W2567161010 creator A5025947755 @default.
• W2567161010 creator A5028277558 @default.
• W2567161010 creator A5034353434 @default.
• W2567161010 creator A5036399045 @default.
• W2567161010 creator A5041999576 @default.
• W2567161010 creator A5048761144 @default.
• W2567161010 creator A5055615940 @default.
• W2567161010 creator A5078878076 @default.
• W2567161010 date "2016-12-29" @default.
• W2567161010 modified "2023-10-11" @default.
• W2567161010 title "COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation" @default.
• W2567161010 cites W1964198430 @default.
• W2567161010 cites W1974567018 @default.
• W2567161010 cites W1993984639 @default.
• W2567161010 cites W1995283634 @default.
• W2567161010 cites W2004632880 @default.
• W2567161010 cites W2015446431 @default.
• W2567161010 cites W2015697722 @default.
• W2567161010 cites W2033870320 @default.
• W2567161010 cites W2045440958 @default.
• W2567161010 cites W2046874204 @default.
• W2567161010 cites W2056457534 @default.
• W2567161010 cites W2080750167 @default.
• W2567161010 cites W2088923206 @default.
• W2567161010 cites W2106403351 @default.
• W2567161010 cites W2112394419 @default.
• W2567161010 cites W2115050770 @default.
• W2567161010 cites W2137628287 @default.
• W2567161010 cites W2148296899 @default.
• W2567161010 cites W2164806144 @default.
• W2567161010 cites W2167285195 @default.
• W2567161010 cites W2336106098 @default.
• W2567161010 cites W2340654372 @default.
• W2567161010 cites W2499446283 @default.
• W2567161010 cites W2518376660 @default.
• W2567161010 cites W831180972 @default.
• W2567161010 doi "https://doi.org/10.18632/oncotarget.14363" @default.
• W2567161010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5354651" @default.
• W2567161010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28052039" @default.
• W2567161010 hasPublicationYear "2016" @default.
• W2567161010 type Work @default.
• W2567161010 sameAs 2567161010 @default.
• W2567161010 citedByCount "11" @default.
• W2567161010 countsByYear W25671610102018 @default.
• W2567161010 countsByYear W25671610102020 @default.
• W2567161010 countsByYear W25671610102021 @default.
• W2567161010 countsByYear W25671610102022 @default.
• W2567161010 countsByYear W25671610102023 @default.
• W2567161010 crossrefType "journal-article" @default.
• W2567161010 hasAuthorship W2567161010A5006572085 @default.
• W2567161010 hasAuthorship W2567161010A5007641864 @default.
• W2567161010 hasAuthorship W2567161010A5010776860 @default.
• W2567161010 hasAuthorship W2567161010A5023713376 @default.
• W2567161010 hasAuthorship W2567161010A5025319461 @default.
• W2567161010 hasAuthorship W2567161010A5025947755 @default.
• W2567161010 hasAuthorship W2567161010A5028277558 @default.
• W2567161010 hasAuthorship W2567161010A5034353434 @default.
• W2567161010 hasAuthorship W2567161010A5036399045 @default.
• W2567161010 hasAuthorship W2567161010A5041999576 @default.
• W2567161010 hasAuthorship W2567161010A5048761144 @default.
• W2567161010 hasAuthorship W2567161010A5055615940 @default.
• W2567161010 hasAuthorship W2567161010A5078878076 @default.
• W2567161010 hasBestOaLocation W25671610101 @default.
• W2567161010 hasConcept C104317684 @default.
• W2567161010 hasConcept C121608353 @default.
• W2567161010 hasConcept C126322002 @default.
• W2567161010 hasConcept C127561419 @default.
• W2567161010 hasConcept C134018914 @default.
• W2567161010 hasConcept C185592680 @default.
• W2567161010 hasConcept C199835354 @default.
• W2567161010 hasConcept C2779131090 @default.
• W2567161010 hasConcept C2779721657 @default.
• W2567161010 hasConcept C2779881121 @default.
• W2567161010 hasConcept C2780091579 @default.
• W2567161010 hasConcept C2780402116 @default.
• W2567161010 hasConcept C29537977 @default.
• W2567161010 hasConcept C502942594 @default.
• W2567161010 hasConcept C55493867 @default.
• W2567161010 hasConcept C62112901 @default.
• W2567161010 hasConcept C71924100 @default.
• W2567161010 hasConcept C98274493 @default.
• W2567161010 hasConceptScore W2567161010C104317684 @default.
• W2567161010 hasConceptScore W2567161010C121608353 @default.
• W2567161010 hasConceptScore W2567161010C126322002 @default.
• W2567161010 hasConceptScore W2567161010C127561419 @default.
• W2567161010 hasConceptScore W2567161010C134018914 @default.
• W2567161010 hasConceptScore W2567161010C185592680 @default.
• W2567161010 hasConceptScore W2567161010C199835354 @default.
• W2567161010 hasConceptScore W2567161010C2779131090 @default.
• W2567161010 hasConceptScore W2567161010C2779721657 @default.
• W2567161010 hasConceptScore W2567161010C2779881121 @default.
• W2567161010 hasConceptScore W2567161010C2780091579 @default.
• W2567161010 hasConceptScore W2567161010C2780402116 @default.

• next