Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567210166> ?p ?o ?g. }
- W2567210166 endingPage "54" @default.
- W2567210166 startingPage "49" @default.
- W2567210166 abstract "Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in transgenic mouse models, LEC-specific loss of CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, impairs lymphatic development. LECs use fatty acid β-oxidation to proliferate and for epigenetic regulation of lymphatic marker expression during LEC differentiation. Mechanistically, the transcription factor PROX1 upregulates CPT1A expression, which increases acetyl coenzyme A production dependent on fatty acid β-oxidation. Acetyl coenzyme A is used by the histone acetyltransferase p300 to acetylate histones at lymphangiogenic genes. PROX1-p300 interaction facilitates preferential histone acetylation at PROX1-target genes. Through this metabolism-dependent mechanism, PROX1 mediates epigenetic changes that promote lymphangiogenesis. Notably, blockade of CPT1 enzymes inhibits injury-induced lymphangiogenesis, and replenishing acetyl coenzyme A by supplementing acetate rescues this process in vivo." @default.
- W2567210166 created "2017-01-06" @default.
- W2567210166 creator A5000233630 @default.
- W2567210166 creator A5003640830 @default.
- W2567210166 creator A5006056577 @default.
- W2567210166 creator A5009362044 @default.
- W2567210166 creator A5010541278 @default.
- W2567210166 creator A5015816803 @default.
- W2567210166 creator A5023311271 @default.
- W2567210166 creator A5027967421 @default.
- W2567210166 creator A5028713739 @default.
- W2567210166 creator A5032896520 @default.
- W2567210166 creator A5034103031 @default.
- W2567210166 creator A5035426620 @default.
- W2567210166 creator A5036342781 @default.
- W2567210166 creator A5038246736 @default.
- W2567210166 creator A5038297299 @default.
- W2567210166 creator A5040996304 @default.
- W2567210166 creator A5043975935 @default.
- W2567210166 creator A5046119875 @default.
- W2567210166 creator A5047152113 @default.
- W2567210166 creator A5056236473 @default.
- W2567210166 creator A5056358339 @default.
- W2567210166 creator A5057422837 @default.
- W2567210166 creator A5058601352 @default.
- W2567210166 creator A5070385304 @default.
- W2567210166 creator A5070764565 @default.
- W2567210166 creator A5078760536 @default.
- W2567210166 creator A5081498592 @default.
- W2567210166 creator A5082891573 @default.
- W2567210166 creator A5084744120 @default.
- W2567210166 creator A5088679649 @default.
- W2567210166 creator A5089019914 @default.
- W2567210166 creator A5089688879 @default.
- W2567210166 creator A5090423367 @default.
- W2567210166 date "2016-12-26" @default.
- W2567210166 modified "2023-10-13" @default.
- W2567210166 title "The role of fatty acid β-oxidation in lymphangiogenesis" @default.
- W2567210166 cites W1587804137 @default.
- W2567210166 cites W1980202624 @default.
- W2567210166 cites W1980596131 @default.
- W2567210166 cites W1986244792 @default.
- W2567210166 cites W1991298929 @default.
- W2567210166 cites W1994961642 @default.
- W2567210166 cites W1995827055 @default.
- W2567210166 cites W1997923564 @default.
- W2567210166 cites W2002106645 @default.
- W2567210166 cites W2017914983 @default.
- W2567210166 cites W2022222857 @default.
- W2567210166 cites W2022280349 @default.
- W2567210166 cites W2026206203 @default.
- W2567210166 cites W2031837508 @default.
- W2567210166 cites W2039879202 @default.
- W2567210166 cites W2043249221 @default.
- W2567210166 cites W2050626482 @default.
- W2567210166 cites W2062573649 @default.
- W2567210166 cites W2066551890 @default.
- W2567210166 cites W2074390128 @default.
- W2567210166 cites W2075131851 @default.
- W2567210166 cites W2075209047 @default.
- W2567210166 cites W2092619818 @default.
- W2567210166 cites W2095619115 @default.
- W2567210166 cites W2096156778 @default.
- W2567210166 cites W2096608993 @default.
- W2567210166 cites W2097731330 @default.
- W2567210166 cites W2105230781 @default.
- W2567210166 cites W2109073916 @default.
- W2567210166 cites W2113265524 @default.
- W2567210166 cites W2114104545 @default.
- W2567210166 cites W2119311666 @default.
- W2567210166 cites W2127725503 @default.
- W2567210166 cites W2131785738 @default.
- W2567210166 cites W2133684738 @default.
- W2567210166 cites W2135712089 @default.
- W2567210166 cites W2136108853 @default.
- W2567210166 cites W2138019675 @default.
- W2567210166 cites W2138047370 @default.
- W2567210166 cites W2140983073 @default.
- W2567210166 cites W2144575277 @default.
- W2567210166 cites W2149346943 @default.
- W2567210166 cites W2151311370 @default.
- W2567210166 cites W2157603347 @default.
- W2567210166 cites W2160167323 @default.
- W2567210166 cites W2171808845 @default.
- W2567210166 cites W2176273377 @default.
- W2567210166 doi "https://doi.org/10.1038/nature21028" @default.
- W2567210166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28024299" @default.
- W2567210166 hasPublicationYear "2016" @default.
- W2567210166 type Work @default.
- W2567210166 sameAs 2567210166 @default.
- W2567210166 citedByCount "224" @default.
- W2567210166 countsByYear W25672101662017 @default.
- W2567210166 countsByYear W25672101662018 @default.
- W2567210166 countsByYear W25672101662019 @default.
- W2567210166 countsByYear W25672101662020 @default.
- W2567210166 countsByYear W25672101662021 @default.
- W2567210166 countsByYear W25672101662022 @default.
- W2567210166 countsByYear W25672101662023 @default.