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- W2567216857 abstract "Introduction: Omalizumab (OMA) is an add-on therapy used to treat moderate to severe allergic asthma patients uncontrolled on inhaled corticosteroids. Understanding characteristics of patients prescribed OMA is relevant for its cost-effective use. Aims: To investigate the socio-demographic, clinical and healthcare resource factors associated with the likelihood of receiving OMA treatment. Methods: We conducted a nested case-control study of patients (age ≥ 12) with moderate to severe allergic asthma from 2006–2012 in a US claims database. Cases (each OMA-recipient) were matched to controls (4 non-OMA-recipients) with equivalent time since cohort index date. Potential determinants for OMA prescription included: demographics, comorbidities, different measures of severity, resource utilization and costs. Results: From 22,952 moderate to severe allergic asthma patients, we identified 356 OMA cases then selected 1,424 controls. Patients were more likely to receive OMA 12 months pre-case/control date if they: were severe vs. moderate (OR adj =1.60, 1.05-2.46); were persistently severe (over prior 12 months) (OR adj =2.21, 1.30-3.77) or oscillating severe (OR adj =3.52, 2.47-5.04) vs persistently moderate; had ≥1 episode of poor asthma control (OR adj =2.85, 2.06-3.93);pre-case date had 1 unit increase in Charlson index (OR adj =1.25, 1.12-1.39), or had $1000 increase in healthcare costs (OR adj =1.16, 1.10-1.22). Conclusions: Disease severity was the strongest determinant of receiving OMA. However, patients that oscillate between moderate and severe disease appear to receive OMA more frequently than those that are persistently severe." @default.
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- W2567216857 date "2015-09-01" @default.
- W2567216857 modified "2023-09-23" @default.
- W2567216857 title "Asthma severity, poor control, co-morbidities and prior resource use determined omalizumab prescriptions in a nested case-control study with US claims data" @default.
- W2567216857 doi "https://doi.org/10.1183/13993003.congress-2015.pa1064" @default.
- W2567216857 hasPublicationYear "2015" @default.
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