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- W2567221591 abstract "Cardiovascular diseases remain the major cause of death throughout the world and can be primarily attributed to atherosclerotic vascular disease leading to stroke and coronary heart disease (CHD). Improved primary prevention and the introductionand subsequent optimization of percutaneous coronary interventions (PCI) for myocardial ischemia due to obstructive CHD have significantly improved patient outcome and reduced morbidity and mortality. The insight into disease pathology has however expanded tremendously over the past decade and continuing research hasshifted the focus of interest towards post-interventional accelerated atherosclerosis development due to a dysfunctional (auto) immune inflammatory response, responsiblefor vascular remodeling, re-occlusion and recurrence of symptoms.The aim of this thesis therefore was to investigate the role of the immune system in this pathophysiological process that ultimately results in post-interventional atheroscleroticvascular remodeling and apply this insight for the development of new immune-modulatory therapies in a preclinical setting." @default.
- W2567221591 created "2017-01-06" @default.
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- W2567221591 date "2013-05-23" @default.
- W2567221591 modified "2023-09-27" @default.
- W2567221591 title "Post-interventional atherosclerotic vascular remodeling : preclinical investigation into immune-modulatory therapies" @default.
- W2567221591 hasPublicationYear "2013" @default.
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