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- W2567301394 abstract "Background: Currently spirometry is widely clinically used to assess adults and children with asthma. However spirometry does not always correlate strongly with asthma control and particularly in children, may be normal despite severe disease. There is a need for more sensitive lung function tests. The aim of this study was to determine if LCI can distinguish children aged 6- 17 years with mild- moderate and severe asthma. Hypothesis: LCI measurements relate to asthma severity and asthma control more than spirometry. Methods: This study included children aged 6-17 years with mild- moderate asthma (MMA) and severe asthma attending the paediatric outpatient clinic of the Royal Brompton Hospital. Patients were recruited prospectively and retrospectively. Results: 79 school aged children with asthma were included. There was a significant difference in LCI between MMA (N=32) and severe asthma (N=47). (P Discussion: Limitations of this study were that there was no healthy control group and patients were recruited at the Royal Brompton Hospital only which is a tertiary hospital with possibly different levels of compliance of medication use and more aggressive treatment. The clinical value of LCI remains uncertain because so many children with severe and mild- moderate asthma still have LCI in normal range. Conclusion: LCI can distinguish asthma severity better than spirometry (FEV1%). But the clinical value of LCI remains uncertain." @default.
- W2567301394 created "2017-01-06" @default.
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- W2567301394 date "2015-09-01" @default.
- W2567301394 modified "2023-09-27" @default.
- W2567301394 title "Addressing current gaps in the clinical utility of lung clearance index (LCI) in school aged children with asthma" @default.
- W2567301394 doi "https://doi.org/10.1183/13993003.congress-2015.pa3640" @default.
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