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• W2567336140 abstract "Abstract Acute lymphoblastic leukemia (ALL) is a heterogeneous disease, and the long-term survival varies with different ages. We performed a retrospective analysis of 122 newly diagnosed adults with standard-risk ALL treated with Escherichia coli asparaginase ( E. coli -asparaginase, n = 50) and polyethylene glycol-conjugated asparaginase (PEG-asparaginase, n = 72). No treatment-related mortality (TRM) occurred in the E. coli -asparaginase group, and 3 TRM events occurred in the PEG-asparaginase group without relation to asparaginase. In addition, 22 (44.0%) and 48 (66.7%) patients achieved a complete response (CR) on day 14 in the E. coli -asparaginase and PEG-asparaginase groups, respectively ( P = 0.032). No different 5-year event-free survival (EFS) or overall survival (OS) rate ( P = 0.632 and 0.769) was observed. Multivariate analysis revealed later CR ( P = 0.008) and older age ( P = 0.049) as adverse prognostic factors for both EFS and OS. In addition, we specifically monitored the known adverse effects of asparaginase, and no asparaginase-related death was observed. Allergy occurred in 9 patients using E. coli -asparaginase, and no patient in the PEG-asparaginase group suffered from allergies ( P <0.001). The incidence of other asparaginase-related toxicities was similar. We conclude that PEG-asparaginase can be safely and effectively used as asparaginase in adults with newly diagnosed standard-risk ALL." @default.
• W2567336140 created "2017-01-06" @default.
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• W2567336140 date "2016-12-21" @default.
• W2567336140 modified "2023-10-17" @default.
• W2567336140 title "Use of PEG-asparaginase in newly diagnosed adults with standard-risk acute lymphoblastic leukemia compared with E. coli-asparaginase: a retrospective single-center study" @default.
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• W2567336140 doi "https://doi.org/10.1038/srep39463" @default.
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