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- W2567362593 endingPage "735" @default.
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- W2567362593 abstract "Cell adhesion-mediated resistance limits the success of cancer therapies and is a great obstacle to overcome in the clinic. Since the 1990s, where it became clear that adhesion of tumor cells to the extracellular matrix is an important mediator of therapy resistance, a lot of work has been conducted to understand the fundamental underlying mechanisms and two paradigms were deduced: cell adhesion-mediated radioresistance (CAM-RR) and cell adhesion-mediated drug resistance (CAM-DR). Preclinical work has evidently demonstrated that targeting of integrins, adapter proteins and associated kinases comprising the cell adhesion resistome is a promising strategy to sensitize cancer cells to both radiotherapy and chemotherapy. Moreover, the cell adhesion resistome fundamentally contributes to adaptation mechanisms induced by radiochemotherapy as well as molecular drugs to secure a balanced homeostasis of cancer cells for survival and growth. Intriguingly, this phenomenon provides a basis for synthetic lethal targeted therapies simultaneously administered to standard radiochemotherapy. In this review, we summarize current knowledge about the cell adhesion resistome and highlight targeting strategies to override CAM-RR and CAM-DR." @default.
- W2567362593 created "2017-01-06" @default.
- W2567362593 creator A5005012409 @default.
- W2567362593 creator A5039794800 @default.
- W2567362593 date "2017-06-27" @default.
- W2567362593 modified "2023-09-26" @default.
- W2567362593 title "The cancer cell adhesion resistome: mechanisms, targeting and translational approaches" @default.
- W2567362593 cites W1503431777 @default.
- W2567362593 cites W1528751727 @default.
- W2567362593 cites W1529267387 @default.
- W2567362593 cites W1535920137 @default.
- W2567362593 cites W1564979199 @default.
- W2567362593 cites W1570846537 @default.
- W2567362593 cites W1598661487 @default.
- W2567362593 cites W1599319991 @default.
- W2567362593 cites W162713377 @default.
- W2567362593 cites W1632032929 @default.
- W2567362593 cites W1715707987 @default.
- W2567362593 cites W1902804987 @default.
- W2567362593 cites W1912124796 @default.
- W2567362593 cites W1916715636 @default.
- W2567362593 cites W1964010639 @default.
- W2567362593 cites W1967449699 @default.
- W2567362593 cites W1968324001 @default.
- W2567362593 cites W1968490536 @default.
- W2567362593 cites W1969342647 @default.
- W2567362593 cites W1970843209 @default.
- W2567362593 cites W1971045882 @default.
- W2567362593 cites W1972851475 @default.
- W2567362593 cites W1973293499 @default.
- W2567362593 cites W1973750369 @default.
- W2567362593 cites W1974468502 @default.
- W2567362593 cites W1975046646 @default.
- W2567362593 cites W1976796981 @default.
- W2567362593 cites W1977880258 @default.
- W2567362593 cites W1980229989 @default.
- W2567362593 cites W1981462495 @default.
- W2567362593 cites W1983072511 @default.
- W2567362593 cites W1983385537 @default.
- W2567362593 cites W1986383962 @default.
- W2567362593 cites W1988669425 @default.
- W2567362593 cites W1989658262 @default.
- W2567362593 cites W1989780564 @default.
- W2567362593 cites W1990105301 @default.
- W2567362593 cites W1990526896 @default.
- W2567362593 cites W1990723931 @default.
- W2567362593 cites W1991048336 @default.
- W2567362593 cites W1991083835 @default.
- W2567362593 cites W1993006648 @default.
- W2567362593 cites W1993907971 @default.
- W2567362593 cites W1994825452 @default.
- W2567362593 cites W1994843494 @default.
- W2567362593 cites W1996931862 @default.
- W2567362593 cites W1998357792 @default.
- W2567362593 cites W1999932868 @default.
- W2567362593 cites W2000096403 @default.
- W2567362593 cites W2000723196 @default.
- W2567362593 cites W2000845191 @default.
- W2567362593 cites W2000983089 @default.
- W2567362593 cites W2003167874 @default.
- W2567362593 cites W2004333139 @default.
- W2567362593 cites W2005022564 @default.
- W2567362593 cites W2007725137 @default.
- W2567362593 cites W2013294222 @default.
- W2567362593 cites W2014977509 @default.
- W2567362593 cites W2015176250 @default.
- W2567362593 cites W2016464728 @default.
- W2567362593 cites W2017951227 @default.
- W2567362593 cites W2018448673 @default.
- W2567362593 cites W2020904443 @default.
- W2567362593 cites W2024558090 @default.
- W2567362593 cites W2024912805 @default.
- W2567362593 cites W2025018535 @default.
- W2567362593 cites W2025491936 @default.
- W2567362593 cites W2025871101 @default.
- W2567362593 cites W2027894597 @default.
- W2567362593 cites W2029583475 @default.
- W2567362593 cites W2031648890 @default.
- W2567362593 cites W2031683597 @default.
- W2567362593 cites W2034710767 @default.
- W2567362593 cites W2034726139 @default.
- W2567362593 cites W2037060648 @default.
- W2567362593 cites W2037628050 @default.
- W2567362593 cites W2043818488 @default.
- W2567362593 cites W2044423100 @default.
- W2567362593 cites W2046713135 @default.
- W2567362593 cites W2049264404 @default.
- W2567362593 cites W2050108686 @default.
- W2567362593 cites W2053911419 @default.
- W2567362593 cites W2056977288 @default.
- W2567362593 cites W2058085176 @default.
- W2567362593 cites W2059188737 @default.
- W2567362593 cites W2059574458 @default.
- W2567362593 cites W2060559298 @default.
- W2567362593 cites W2060830074 @default.
- W2567362593 cites W2063897621 @default.
- W2567362593 cites W2065264929 @default.
- W2567362593 cites W2066616821 @default.