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• W2567367887 abstract "Ammonia-induced mitochondrial dysfunction and energy crisis is known as a critical consequence of hepatic encephalopathy (HE). Hence, mitochondria are potential targets of therapy in HE. The current investigation was designed to evaluate the role of taurine treatment on the brain and liver mitochondrial function in a rat model of hepatic encephalopathy and hyperammonemia. The animals received thioacetamide (400 mg/kg, i.p, for three consecutive days at 24-h intervals) as a model of acute liver failure and hyperammonemia. Several biochemical parameters were investigated in the serum, while the animals’ cognitive function and locomotor activity were monitored. Mitochondria was isolated from the rats’ brain and liver and several indices were assessed in isolated mitochondria. Liver failure led to cognitive dysfunction and impairment in locomotor activity in the rats. Plasma and brain ammonia was high and serum markers of liver injury were drastically elevated in the thioacetamide-treated group. An assessment of brain and liver mitochondrial function in the thioacetamide-treated animals revealed an inhibition of succinate dehydrogenase activity (SDA), collapsed mitochondrial membrane potential, mitochondrial swelling, and increased reactive oxygen species (ROS). Furthermore, a significant decrease in mitochondrial ATP was detected in the brain and liver mitochondria isolated from thioacetamide-treated animals. Taurine treatment (250, 500, and 1000 mg/kg) decreased mitochondrial swelling, ROS, and LPO. Moreover, the administration of this amino acid restored brain and liver mitochondrial ATP. These data suggest taurine to be a potential protective agent with therapeutic capability against hepatic encephalopathy and hyperammonemia-induced mitochondrial dysfunction and energy crisis." @default.
• W2567367887 created "2017-01-06" @default.
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• W2567367887 date "2017-02-01" @default.
• W2567367887 modified "2023-10-05" @default.
• W2567367887 title "Taurine treatment preserves brain and liver mitochondrial function in a rat model of fulminant hepatic failure and hyperammonemia" @default.
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• W2567367887 cites W1750124678 @default.
• W2567367887 cites W1963610615 @default.
• W2567367887 cites W1966575277 @default.
• W2567367887 cites W1969260386 @default.
• W2567367887 cites W1969992365 @default.
• W2567367887 cites W1970718497 @default.
• W2567367887 cites W1972258793 @default.
• W2567367887 cites W1974619516 @default.
• W2567367887 cites W1976869572 @default.
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• W2567367887 cites W1996555331 @default.
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• W2567367887 cites W1997725987 @default.
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• W2567367887 cites W2001059449 @default.
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• W2567367887 cites W2011473644 @default.
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• W2567367887 cites W2023874086 @default.
• W2567367887 cites W2032773883 @default.
• W2567367887 cites W2035918887 @default.
• W2567367887 cites W2041647802 @default.
• W2567367887 cites W2050268779 @default.
• W2567367887 cites W2055086154 @default.
• W2567367887 cites W2062146677 @default.
• W2567367887 cites W2077449299 @default.
• W2567367887 cites W2079439158 @default.
• W2567367887 cites W2084715340 @default.
• W2567367887 cites W2087790613 @default.
• W2567367887 cites W2088255899 @default.
• W2567367887 cites W2092507269 @default.
• W2567367887 cites W2097700658 @default.
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• W2567367887 cites W2119661815 @default.
• W2567367887 cites W2121230618 @default.
• W2567367887 cites W2124622312 @default.
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• W2567367887 doi "https://doi.org/10.1016/j.biopha.2016.11.095" @default.
• W2567367887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28024286" @default.
• W2567367887 hasPublicationYear "2017" @default.
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