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- W2567425592 abstract "Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic external surface, allows these substances to spontaneously complex poorly soluble compounds in an aqueous environment. For more than 50 years, these substances have found applicability in the pharmaceutical and food industries as solubilizing agents for poorly soluble chemical entities. Nowadays, several research groups all over the world are investigating their potential as active pharmaceutical ingredients (APIs) for the treatment of several illnesses (e.g., hypercholesterolemia, cancer, Niemann-Pick Type C disease). The aim of this review is to briefly retrace cyclodextrins’ legacy as complexing agents and describe the current and future prospects of this class of chemical entities in pharmaceutics as new APIs." @default.
- W2567425592 created "2017-01-06" @default.
- W2567425592 creator A5062596893 @default.
- W2567425592 date "2016-12-25" @default.
- W2567425592 modified "2023-10-06" @default.
- W2567425592 title "The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview" @default.
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- W2567425592 doi "https://doi.org/10.3390/molecules22010001" @default.
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