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- W2567450897 abstract "Scleroderma renal crisis (SRC) is the consequence of renal microvasculopathy with thickened capillary walls and microthrombosis. SRC represents a severe acute compli- cation, however involving less than 5% of all scleroderma patients. Physicians should be aware of SRC risk in case of new-onset hypertension occurring in a scleroderma patient. In 10% of cases, blood pressure is normal. SRC occurs most often during the first four years of the disease. Corticoste- roids at high doses (>15 mg/day of prednisone equivalent) may induce SRC. SRC combines acute renal failure, hemo- lytic anemia with schizocytosis, sometimes thrombocytope- nia, proteinuria and hematuria. Renal vasculitis (with anti- myeloperoxydase antibodies) or cryoglobulinemia vasculitis are the two main differential diagnoses to rule out. When sys- temic sclerodermia is not known, SRC should be considered in any presentation combining hypertensive crisis and acute kidney injury. Sclerodermia diagnosis is based upon clinical examination. Despite angiotensin-converting-enzyme inhibi- tors and supportive treatments, SRC prognosis remains severe with 20% mortality rate at one year. Dialysis is needed in approximately two thirds of the cases and further permanently in three quarters of them. Nevertheless, recovery of renal function may be obtained during the first two years after SRC, leading thus not to recommend renal transplantation before this period of two years." @default.
- W2567450897 created "2017-01-06" @default.
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- W2567450897 date "2014-01-01" @default.
- W2567450897 modified "2023-10-14" @default.
- W2567450897 title "Scleroderma Renal Crisis" @default.
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