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• W2567466572 endingPage "364" @default.
• W2567466572 startingPage "352" @default.
• W2567466572 abstract "Biochemical, biophysical, and bioelectrical signaling cues control cardiac myocyte differentiation, maturation, and physiology. These signals may be mediated via cell–cell and cell–extracellular matrix interactions. The development of cellular models of human myocardial physiology and pathophysiology requires the adaptation of these cues for in vitro applications. A cardiogenic biochemical milieu can be enforced in vitro via small-molecule modulation of Wnt signaling. Cardiogenic biophysical cues can be adapted in vitro by controlling growth substrate topography and elasticity, generating 3D myocardial tissue, and applying mechanical stress to cells and tissues. Electrical point stimulation provides physiologic bioelectrical cues and is dependent on cell–cell interactions for signal propagation. Electrical field stimulation is suitable for excitation of cell islands or clusters in vitro and ensures synchronous contraction of myocardial cells. The advent of human pluripotent stem cell (hPSC) biology has opened unprecedented opportunities for the use of tissue engineering to generate human cardiac tissue for in vitro study. Engineering cardiac constructs that recapitulate human development and disease requires faithful recreation of the cardiac niche in vitro. Here we discuss recent progress in translating the in vivo cardiac microenvironment into PSC models of the human heart. We review three key physiologic features required to recreate the cardiac niche and facilitate normal cardiac differentiation and maturation: the biochemical, biophysical, and bioelectrical signaling cues. Finally, we discuss key barriers that must be overcome to fulfill the promise of stem cell biology in preclinical applications and ultimately in clinical practice. The advent of human pluripotent stem cell (hPSC) biology has opened unprecedented opportunities for the use of tissue engineering to generate human cardiac tissue for in vitro study. Engineering cardiac constructs that recapitulate human development and disease requires faithful recreation of the cardiac niche in vitro. Here we discuss recent progress in translating the in vivo cardiac microenvironment into PSC models of the human heart. We review three key physiologic features required to recreate the cardiac niche and facilitate normal cardiac differentiation and maturation: the biochemical, biophysical, and bioelectrical signaling cues. Finally, we discuss key barriers that must be overcome to fulfill the promise of stem cell biology in preclinical applications and ultimately in clinical practice." @default.
• W2567466572 created "2017-01-06" @default.
• W2567466572 creator A5063761119 @default.
• W2567466572 creator A5088957999 @default.
• W2567466572 date "2017-05-01" @default.
• W2567466572 modified "2023-10-16" @default.
• W2567466572 title "Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease" @default.
• W2567466572 cites W1480171680 @default.
• W2567466572 cites W1577117193 @default.
• W2567466572 cites W1820605760 @default.
• W2567466572 cites W1821166167 @default.
• W2567466572 cites W1936727810 @default.
• W2567466572 cites W1950279850 @default.
• W2567466572 cites W1964086310 @default.
• W2567466572 cites W1966127544 @default.
• W2567466572 cites W1966416420 @default.
• W2567466572 cites W1969193847 @default.
• W2567466572 cites W1970288681 @default.
• W2567466572 cites W1970526294 @default.
• W2567466572 cites W1971163936 @default.
• W2567466572 cites W1974388426 @default.
• W2567466572 cites W1975396117 @default.
• W2567466572 cites W1976646890 @default.
• W2567466572 cites W1977025496 @default.
• W2567466572 cites W1979279272 @default.
• W2567466572 cites W1979955583 @default.
• W2567466572 cites W1983625237 @default.
• W2567466572 cites W1984977541 @default.
• W2567466572 cites W1987122042 @default.
• W2567466572 cites W1988011074 @default.
• W2567466572 cites W1988451304 @default.
• W2567466572 cites W1990864926 @default.
• W2567466572 cites W1992657103 @default.
• W2567466572 cites W1996413925 @default.
• W2567466572 cites W1998190377 @default.
• W2567466572 cites W2005796050 @default.
• W2567466572 cites W2006812487 @default.
• W2567466572 cites W2009110094 @default.
• W2567466572 cites W2010020475 @default.
• W2567466572 cites W2010417854 @default.
• W2567466572 cites W2011844821 @default.
• W2567466572 cites W2016279653 @default.
• W2567466572 cites W2018463503 @default.
• W2567466572 cites W2022229270 @default.
• W2567466572 cites W2023315677 @default.
• W2567466572 cites W2026404421 @default.
• W2567466572 cites W2030846416 @default.
• W2567466572 cites W2035312069 @default.
• W2567466572 cites W2039276611 @default.
• W2567466572 cites W2039580049 @default.
• W2567466572 cites W2044726736 @default.
• W2567466572 cites W2045295282 @default.
• W2567466572 cites W2045626197 @default.
• W2567466572 cites W2047072339 @default.
• W2567466572 cites W2048255936 @default.
• W2567466572 cites W2048644480 @default.
• W2567466572 cites W2048722591 @default.
• W2567466572 cites W2050818720 @default.
• W2567466572 cites W2054738773 @default.
• W2567466572 cites W2054850711 @default.
• W2567466572 cites W2057937307 @default.
• W2567466572 cites W2058206852 @default.
• W2567466572 cites W2059367897 @default.
• W2567466572 cites W2062145052 @default.
• W2567466572 cites W2062164427 @default.
• W2567466572 cites W2063151064 @default.
• W2567466572 cites W2064019624 @default.
• W2567466572 cites W2064227310 @default.
• W2567466572 cites W2064297038 @default.
• W2567466572 cites W2065174416 @default.
• W2567466572 cites W2066390373 @default.
• W2567466572 cites W2066767635 @default.
• W2567466572 cites W2067214401 @default.
• W2567466572 cites W2068796176 @default.
• W2567466572 cites W2075928340 @default.
• W2567466572 cites W2077587455 @default.
• W2567466572 cites W2080218770 @default.
• W2567466572 cites W2080499872 @default.
• W2567466572 cites W2081720885 @default.
• W2567466572 cites W2085320707 @default.
• W2567466572 cites W2086444909 @default.
• W2567466572 cites W2088906649 @default.
• W2567466572 cites W2091445641 @default.
• W2567466572 cites W2093261617 @default.
• W2567466572 cites W2093494581 @default.
• W2567466572 cites W2094060804 @default.
• W2567466572 cites W2096237299 @default.
• W2567466572 cites W2098188264 @default.
• W2567466572 cites W2098268167 @default.
• W2567466572 cites W2100982253 @default.
• W2567466572 cites W2100989502 @default.
• W2567466572 cites W2101228997 @default.
• W2567466572 cites W2101986300 @default.
• W2567466572 cites W2104475665 @default.
• W2567466572 cites W2105734290 @default.
• W2567466572 cites W2105955220 @default.
• W2567466572 cites W2106644177 @default.
• W2567466572 cites W2107556826 @default.

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