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• W2567490015 startingPage "e122" @default.
• W2567490015 abstract "Replacement, reduction and refinement (the 3R's) are the leading principles in translational research with animals. To be useful a model should also be clinically Relevant (the 4th R). Work in a non-human primate model of multiple sclerosis, the experimental autoimmune encephalomyelitis model, reveals an inherent conflict among these 4R principles. The impossibility to harmonize all 4R's forms a major challenge when the model is applied in preclinical drug development." @default.
• W2567490015 created "2017-01-06" @default.
• W2567490015 creator A5036389128 @default.
• W2567490015 date "2016-12-01" @default.
• W2567490015 modified "2023-10-18" @default.
• W2567490015 title "Primate autoimmune disease models; lost for translation?" @default.
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• W2567490015 doi "https://doi.org/10.1038/cti.2016.82" @default.
• W2567490015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5384286" @default.
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