FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567497199> ?p ?o ?g. }

• W2567497199 endingPage "18" @default.
• W2567497199 startingPage "10" @default.
• W2567497199 abstract "Niemann–Pick type C (NPC) disease, characterized by intracellular accumulation of unesterified cholesterol and other lipids owing to defects in two proteins NPC1 and NPC2, causes neurodegeneration and other fatal neurovisceral symptoms. Currently, treatment of NPC involves the use of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). HP-β-CD is effective in the treatment of hepatosplenomegaly in NPC disease, albeit at a very high dose. One of the methods to reduce the required dose of HP-β-CD for treatment of NPC is to actively targeting hepatocytes with β-cyclodextrin (β-CD). The aim of the present study was to synthesize a novel multi-lactose-appended β-CD (multi-Lac-β-CD) and to evaluate its cholesterol-lowering effect in U18666A-treated HepG2 (NPC-like HepG2) cells. Further, the study aimed at delivering β-CD to hepatocytes via cholesterol-accumulated HepG2 cells, and indicated that the newly synthesized multi-Lac-β-CD had an average degree of substitution of lactose (DSL) of 5.6. This newly synthesized multi-Lac-β-CD was found to significantly decrease the concentration of intracellular cholesterol with negligible cytotoxicity as compared to HP-β-CD. An increased internalization of TRITC-multi-Lac-β-CD (DSL 5.6) as compared to TRITC-HP-β-CD was observed in NPC-like HepG2 cells. Further, the dissociation constant of peanut lectin with multi-Lac-β-CD (DSL5.6) was found to be extremely low (2.5 × 10 −8 M). These results indicate that multi-Lac-β-CD (DSL5.6) diminished intracellular cholesterol levels in NPC-like HepG2 cells via asialoglycoprotein receptor (ASGPR)-mediated endocytosis." @default.
• W2567497199 created "2017-01-06" @default.
• W2567497199 creator A5011330479 @default.
• W2567497199 creator A5027112145 @default.
• W2567497199 creator A5035850424 @default.
• W2567497199 creator A5042808417 @default.
• W2567497199 creator A5056086946 @default.
• W2567497199 creator A5065509304 @default.
• W2567497199 creator A5068587459 @default.
• W2567497199 creator A5078605099 @default.
• W2567497199 creator A5086855818 @default.
• W2567497199 date "2017-01-03" @default.
• W2567497199 modified "2023-10-16" @default.
• W2567497199 title "Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells" @default.
• W2567497199 cites W1513167259 @default.
• W2567497199 cites W1677335197 @default.
• W2567497199 cites W1965122895 @default.
• W2567497199 cites W1967516512 @default.
• W2567497199 cites W1976252335 @default.
• W2567497199 cites W1984927304 @default.
• W2567497199 cites W1998279241 @default.
• W2567497199 cites W2038575282 @default.
• W2567497199 cites W2041595401 @default.
• W2567497199 cites W2044609602 @default.
• W2567497199 cites W2053203314 @default.
• W2567497199 cites W2059375062 @default.
• W2567497199 cites W2065408118 @default.
• W2567497199 cites W2068262899 @default.
• W2567497199 cites W2081072802 @default.
• W2567497199 cites W2096221379 @default.
• W2567497199 cites W2129679875 @default.
• W2567497199 cites W2136116905 @default.
• W2567497199 cites W2147612731 @default.
• W2567497199 cites W2155503300 @default.
• W2567497199 cites W2158140506 @default.
• W2567497199 cites W2165683666 @default.
• W2567497199 cites W2180206035 @default.
• W2567497199 cites W2333729753 @default.
• W2567497199 cites W4231136244 @default.
• W2567497199 doi "https://doi.org/10.3762/bjoc.13.2" @default.
• W2567497199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5238562" @default.
• W2567497199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28179943" @default.
• W2567497199 hasPublicationYear "2017" @default.
• W2567497199 type Work @default.
• W2567497199 sameAs 2567497199 @default.
• W2567497199 citedByCount "15" @default.
• W2567497199 countsByYear W25674971992018 @default.
• W2567497199 countsByYear W25674971992019 @default.
• W2567497199 countsByYear W25674971992020 @default.
• W2567497199 countsByYear W25674971992021 @default.
• W2567497199 countsByYear W25674971992022 @default.
• W2567497199 countsByYear W25674971992023 @default.
• W2567497199 crossrefType "journal-article" @default.
• W2567497199 hasAuthorship W2567497199A5011330479 @default.
• W2567497199 hasAuthorship W2567497199A5027112145 @default.
• W2567497199 hasAuthorship W2567497199A5035850424 @default.
• W2567497199 hasAuthorship W2567497199A5042808417 @default.
• W2567497199 hasAuthorship W2567497199A5056086946 @default.
• W2567497199 hasAuthorship W2567497199A5065509304 @default.
• W2567497199 hasAuthorship W2567497199A5068587459 @default.
• W2567497199 hasAuthorship W2567497199A5078605099 @default.
• W2567497199 hasAuthorship W2567497199A5086855818 @default.
• W2567497199 hasBestOaLocation W25674971991 @default.
• W2567497199 hasConcept C102747710 @default.
• W2567497199 hasConcept C109316439 @default.
• W2567497199 hasConcept C11569505 @default.
• W2567497199 hasConcept C139770010 @default.
• W2567497199 hasConcept C1491633281 @default.
• W2567497199 hasConcept C153911025 @default.
• W2567497199 hasConcept C185592680 @default.
• W2567497199 hasConcept C202751555 @default.
• W2567497199 hasConcept C2776200302 @default.
• W2567497199 hasConcept C2778163477 @default.
• W2567497199 hasConcept C2778552423 @default.
• W2567497199 hasConcept C2779433975 @default.
• W2567497199 hasConcept C28005876 @default.
• W2567497199 hasConcept C55493867 @default.
• W2567497199 hasConcept C79879829 @default.
• W2567497199 hasConcept C86803240 @default.
• W2567497199 hasConceptScore W2567497199C102747710 @default.
• W2567497199 hasConceptScore W2567497199C109316439 @default.
• W2567497199 hasConceptScore W2567497199C11569505 @default.
• W2567497199 hasConceptScore W2567497199C139770010 @default.
• W2567497199 hasConceptScore W2567497199C1491633281 @default.
• W2567497199 hasConceptScore W2567497199C153911025 @default.
• W2567497199 hasConceptScore W2567497199C185592680 @default.
• W2567497199 hasConceptScore W2567497199C202751555 @default.
• W2567497199 hasConceptScore W2567497199C2776200302 @default.
• W2567497199 hasConceptScore W2567497199C2778163477 @default.
• W2567497199 hasConceptScore W2567497199C2778552423 @default.
• W2567497199 hasConceptScore W2567497199C2779433975 @default.
• W2567497199 hasConceptScore W2567497199C28005876 @default.
• W2567497199 hasConceptScore W2567497199C55493867 @default.
• W2567497199 hasConceptScore W2567497199C79879829 @default.
• W2567497199 hasConceptScore W2567497199C86803240 @default.
• W2567497199 hasLocation W25674971991 @default.
• W2567497199 hasLocation W25674971992 @default.
• W2567497199 hasLocation W25674971993 @default.

• next