FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567521254> ?p ?o ?g. }

• W2567521254 endingPage "853" @default.
• W2567521254 startingPage "846" @default.
• W2567521254 abstract "The Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis. Although there are four classes of vaccines against JEV, all of them are administered by s.c or i.m injection. Here, the effectiveness of sublingual (s.l.) administration of a JEV live-attenuated vaccine or recombinant modified vaccinia virus Ankara (MVA) vaccine, including JEV prM/E, was investigated. The mice were immunized three times i.m. or s.c. One week after the final immunization by both s.l. and i.m. routes, the titers of IgG1 induced by the recombinant MVA vaccine were higher than those induced by the live-attenuated vaccine, whereas the titers of IgG2a induced by the live-attenuated vaccine were higher than those induced by the recombinant MVA vaccine. However, both vaccines induced neutralizing antibodies when given by either s.l. or i.m. routes, indicating that both vaccines induce appropriate Th1 and Th2 cell responses through the s.l. and i.m. routes. Moreover, both vaccines protected against induction of proinflammatory cytokines and focal spleen white pulp hyperplasia after viral challenge. Virus-specific IFN-γ+ CD4+ and CD8+ T cells appeared to increase in mice immunized via both s.l. and i.m. routes. Interestingly, virus-specific IL-17+ CD4+ T cells increased significantly only in the mice immunized via the s.l. route; however, the increased IL-17 did not affect pathogenicity after viral challenge. These results suggest that s.l. immunization may be as useful as i.m. injection for induction of protective immune responses against JEV by both live-attenuated and recombinant MVA vaccines." @default.
• W2567521254 created "2017-01-06" @default.
• W2567521254 creator A5011900216 @default.
• W2567521254 creator A5019565977 @default.
• W2567521254 creator A5061698690 @default.
• W2567521254 creator A5064273153 @default.
• W2567521254 creator A5074469887 @default.
• W2567521254 creator A5081119853 @default.
• W2567521254 creator A5081673183 @default.
• W2567521254 creator A5086182270 @default.
• W2567521254 date "2016-12-01" @default.
• W2567521254 modified "2023-10-14" @default.
• W2567521254 title "Sublingual immunization with Japanese encephalitis virus vaccine effectively induces immunity through both cellular and humoral immune responses in mice" @default.
• W2567521254 cites W1488178733 @default.
• W2567521254 cites W1811811056 @default.
• W2567521254 cites W1901008136 @default.
• W2567521254 cites W1976802560 @default.
• W2567521254 cites W1983124094 @default.
• W2567521254 cites W1992082529 @default.
• W2567521254 cites W2002292128 @default.
• W2567521254 cites W2006676898 @default.
• W2567521254 cites W2022750970 @default.
• W2567521254 cites W2030046937 @default.
• W2567521254 cites W2054648552 @default.
• W2567521254 cites W2095543168 @default.
• W2567521254 cites W2118897032 @default.
• W2567521254 cites W2132898662 @default.
• W2567521254 cites W2271017677 @default.
• W2567521254 cites W2345790997 @default.
• W2567521254 cites W2418251017 @default.
• W2567521254 doi "https://doi.org/10.1111/1348-0421.12458" @default.
• W2567521254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28004418" @default.
• W2567521254 hasPublicationYear "2016" @default.
• W2567521254 type Work @default.
• W2567521254 sameAs 2567521254 @default.
• W2567521254 citedByCount "8" @default.
• W2567521254 countsByYear W25675212542017 @default.
• W2567521254 countsByYear W25675212542018 @default.
• W2567521254 countsByYear W25675212542019 @default.
• W2567521254 countsByYear W25675212542020 @default.
• W2567521254 countsByYear W25675212542021 @default.
• W2567521254 crossrefType "journal-article" @default.
• W2567521254 hasAuthorship W2567521254A5011900216 @default.
• W2567521254 hasAuthorship W2567521254A5019565977 @default.
• W2567521254 hasAuthorship W2567521254A5061698690 @default.
• W2567521254 hasAuthorship W2567521254A5064273153 @default.
• W2567521254 hasAuthorship W2567521254A5074469887 @default.
• W2567521254 hasAuthorship W2567521254A5081119853 @default.
• W2567521254 hasAuthorship W2567521254A5081673183 @default.
• W2567521254 hasAuthorship W2567521254A5086182270 @default.
• W2567521254 hasBestOaLocation W25675212541 @default.
• W2567521254 hasConcept C104317684 @default.
• W2567521254 hasConcept C159047783 @default.
• W2567521254 hasConcept C203014093 @default.
• W2567521254 hasConcept C22070199 @default.
• W2567521254 hasConcept C2522874641 @default.
• W2567521254 hasConcept C2778540732 @default.
• W2567521254 hasConcept C2779141303 @default.
• W2567521254 hasConcept C2779341262 @default.
• W2567521254 hasConcept C2780801004 @default.
• W2567521254 hasConcept C54602769 @default.
• W2567521254 hasConcept C55493867 @default.
• W2567521254 hasConcept C60987743 @default.
• W2567521254 hasConcept C83455156 @default.
• W2567521254 hasConcept C86803240 @default.
• W2567521254 hasConcept C8891405 @default.
• W2567521254 hasConceptScore W2567521254C104317684 @default.
• W2567521254 hasConceptScore W2567521254C159047783 @default.
• W2567521254 hasConceptScore W2567521254C203014093 @default.
• W2567521254 hasConceptScore W2567521254C22070199 @default.
• W2567521254 hasConceptScore W2567521254C2522874641 @default.
• W2567521254 hasConceptScore W2567521254C2778540732 @default.
• W2567521254 hasConceptScore W2567521254C2779141303 @default.
• W2567521254 hasConceptScore W2567521254C2779341262 @default.
• W2567521254 hasConceptScore W2567521254C2780801004 @default.
• W2567521254 hasConceptScore W2567521254C54602769 @default.
• W2567521254 hasConceptScore W2567521254C55493867 @default.
• W2567521254 hasConceptScore W2567521254C60987743 @default.
• W2567521254 hasConceptScore W2567521254C83455156 @default.
• W2567521254 hasConceptScore W2567521254C86803240 @default.
• W2567521254 hasConceptScore W2567521254C8891405 @default.
• W2567521254 hasIssue "12" @default.
• W2567521254 hasLocation W25675212541 @default.
• W2567521254 hasLocation W25675212542 @default.
• W2567521254 hasOpenAccess W2567521254 @default.
• W2567521254 hasPrimaryLocation W25675212541 @default.
• W2567521254 hasRelatedWork W1983124094 @default.
• W2567521254 hasRelatedWork W2004688624 @default.
• W2567521254 hasRelatedWork W2028368083 @default.
• W2567521254 hasRelatedWork W2055226225 @default.
• W2567521254 hasRelatedWork W2101540980 @default.
• W2567521254 hasRelatedWork W2188759708 @default.
• W2567521254 hasRelatedWork W2391513725 @default.
• W2567521254 hasRelatedWork W2791292804 @default.
• W2567521254 hasRelatedWork W30101919 @default.
• W2567521254 hasRelatedWork W4230915866 @default.
• W2567521254 hasVolume "60" @default.
• W2567521254 isParatext "false" @default.

• next