Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567522015> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2567522015 endingPage "295" @default.
- W2567522015 startingPage "288" @default.
- W2567522015 abstract "Growing prevalence of diabetes(type 2 as well as type 1) and its related morbidity due to vascular complications creates a large burden on medical care worldwide. Understanding the molecular pathogenesis of chronic micro-, macro- and avascular complications mediated by hyperglycemia is of crucial importance since novel therapeutic targets can be identified and tested. Thiamine(vitamin B1) is an essential cofactor of several enzymes involved in carbohydrate metabolism and published data suggest that thiamine metabolism in diabetes is deficient. This review aims to point out the physiological role of thiamine in metabolism of glucose and amino acids, to present overview of thiamine metabolism and to describe the consequences of thiamine deficiency(either clinically manifest or latent). Furthermore, we want to explain why thiamine demands are increased in diabetes and to summarise data indicating thiamine mishandling in diabetics(by review of the studies mapping the prevalence and the degree ofthiamine deficiency in diabetics). Finally, we would like to summarise the evidence for the beneficial effect of thiamine supplementation in progression of hyperglycemia-related pathology and, therefore, to justify its importance in determining the harmful impact of hyperglycemia in diabetes. Based on the data presented it could be concluded that although experimental studies mostly resulted in beneficial effects, clinical studies of appropriate size and duration focusing on the effect of thiamine supplementation/therapy on hard endpoints are missing at present. Moreover, it is not currently clear which mechanisms contribute to the deficient action of thiamine in diabetes most. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given." @default.
- W2567522015 created "2017-01-06" @default.
- W2567522015 creator A5008042906 @default.
- W2567522015 creator A5008585046 @default.
- W2567522015 creator A5011672084 @default.
- W2567522015 creator A5049393244 @default.
- W2567522015 creator A5066801907 @default.
- W2567522015 creator A5089713553 @default.
- W2567522015 date "2014-01-01" @default.
- W2567522015 modified "2023-09-26" @default.
- W2567522015 title "为在糖尿病的改变的 thiamine 新陈代谢的证据: 有一个潜力由合理补充反对 gluco- 和 lipotoxicity？" @default.
- W2567522015 hasPublicationYear "2014" @default.
- W2567522015 type Work @default.
- W2567522015 sameAs 2567522015 @default.
- W2567522015 citedByCount "0" @default.
- W2567522015 crossrefType "journal-article" @default.
- W2567522015 hasAuthorship W2567522015A5008042906 @default.
- W2567522015 hasAuthorship W2567522015A5008585046 @default.
- W2567522015 hasAuthorship W2567522015A5011672084 @default.
- W2567522015 hasAuthorship W2567522015A5049393244 @default.
- W2567522015 hasAuthorship W2567522015A5066801907 @default.
- W2567522015 hasAuthorship W2567522015A5089713553 @default.
- W2567522015 hasConcept C103432212 @default.
- W2567522015 hasConcept C126322002 @default.
- W2567522015 hasConcept C134018914 @default.
- W2567522015 hasConcept C181199279 @default.
- W2567522015 hasConcept C197957613 @default.
- W2567522015 hasConcept C2776203871 @default.
- W2567522015 hasConcept C2777180221 @default.
- W2567522015 hasConcept C2777958118 @default.
- W2567522015 hasConcept C2780047943 @default.
- W2567522015 hasConcept C55493867 @default.
- W2567522015 hasConcept C555293320 @default.
- W2567522015 hasConcept C60644358 @default.
- W2567522015 hasConcept C71924100 @default.
- W2567522015 hasConcept C86803240 @default.
- W2567522015 hasConceptScore W2567522015C103432212 @default.
- W2567522015 hasConceptScore W2567522015C126322002 @default.
- W2567522015 hasConceptScore W2567522015C134018914 @default.
- W2567522015 hasConceptScore W2567522015C181199279 @default.
- W2567522015 hasConceptScore W2567522015C197957613 @default.
- W2567522015 hasConceptScore W2567522015C2776203871 @default.
- W2567522015 hasConceptScore W2567522015C2777180221 @default.
- W2567522015 hasConceptScore W2567522015C2777958118 @default.
- W2567522015 hasConceptScore W2567522015C2780047943 @default.
- W2567522015 hasConceptScore W2567522015C55493867 @default.
- W2567522015 hasConceptScore W2567522015C555293320 @default.
- W2567522015 hasConceptScore W2567522015C60644358 @default.
- W2567522015 hasConceptScore W2567522015C71924100 @default.
- W2567522015 hasConceptScore W2567522015C86803240 @default.
- W2567522015 hasIssue "3" @default.
- W2567522015 hasLocation W25675220151 @default.
- W2567522015 hasOpenAccess W2567522015 @default.
- W2567522015 hasPrimaryLocation W25675220151 @default.
- W2567522015 isParatext "false" @default.
- W2567522015 isRetracted "false" @default.
- W2567522015 magId "2567522015" @default.
- W2567522015 workType "article" @default.