Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567540060> ?p ?o ?g. }
- W2567540060 endingPage "74" @default.
- W2567540060 startingPage "67" @default.
- W2567540060 abstract "Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that is one of the major causes of viral encephalitis diseases worldwide. The JEV envelope protein facilitates viral entry, and its domain III contains an Arg-Gly-Asp (RGD) motif, that may modulate JEV entry through the RGD-binding integrin. In this study, the roles of integrin αv and β3 on the infection of JEV were evaluated. Reduced expression of integrin αv/β3 by special shRNA confers 2 to 4-fold inhibition of JEV replication in BHK-21 cells. Meanwhile, antibodies specific for integrin αv/β3 displayed ~ 58% and ~ 33% inhibition of JEV infectivity and RGD-specific peptides produced ~ 36% of inhibition. Expression of E protein and JEV RNA loads were clearly increased in CHO cells transfected with cDNA encoding human integrin β3. Moreover, integrin αv mediates JEV infection in viral binding stage of life cycle. Therefore, our study suggested that integrin αv and β3 serve as a host factor associated with JEV entry into the target cells." @default.
- W2567540060 created "2017-01-06" @default.
- W2567540060 creator A5033309555 @default.
- W2567540060 creator A5045767657 @default.
- W2567540060 creator A5050199543 @default.
- W2567540060 creator A5062559507 @default.
- W2567540060 creator A5066231460 @default.
- W2567540060 creator A5074707535 @default.
- W2567540060 creator A5091068751 @default.
- W2567540060 date "2017-04-01" @default.
- W2567540060 modified "2023-10-17" @default.
- W2567540060 title "Integrin αvβ3 promotes infection by Japanese encephalitis virus" @default.
- W2567540060 cites W1480732198 @default.
- W2567540060 cites W1481936865 @default.
- W2567540060 cites W1505196125 @default.
- W2567540060 cites W1576773659 @default.
- W2567540060 cites W1610515357 @default.
- W2567540060 cites W1966979525 @default.
- W2567540060 cites W1968071906 @default.
- W2567540060 cites W1971371194 @default.
- W2567540060 cites W1972431524 @default.
- W2567540060 cites W1976796981 @default.
- W2567540060 cites W2007639993 @default.
- W2567540060 cites W2017329638 @default.
- W2567540060 cites W2023588767 @default.
- W2567540060 cites W2025494340 @default.
- W2567540060 cites W2027751331 @default.
- W2567540060 cites W2030949148 @default.
- W2567540060 cites W2036119279 @default.
- W2567540060 cites W2036562152 @default.
- W2567540060 cites W2038055214 @default.
- W2567540060 cites W2039841791 @default.
- W2567540060 cites W2048006785 @default.
- W2567540060 cites W2048441281 @default.
- W2567540060 cites W2050346793 @default.
- W2567540060 cites W2060560636 @default.
- W2567540060 cites W2063657073 @default.
- W2567540060 cites W2065681560 @default.
- W2567540060 cites W2072897393 @default.
- W2567540060 cites W2077741815 @default.
- W2567540060 cites W2078579838 @default.
- W2567540060 cites W2095247923 @default.
- W2567540060 cites W2105035717 @default.
- W2567540060 cites W2109379906 @default.
- W2567540060 cites W2111463222 @default.
- W2567540060 cites W2115643258 @default.
- W2567540060 cites W2117672421 @default.
- W2567540060 cites W2120784335 @default.
- W2567540060 cites W2122700244 @default.
- W2567540060 cites W2124780069 @default.
- W2567540060 cites W2131388419 @default.
- W2567540060 cites W2134940342 @default.
- W2567540060 cites W2135716413 @default.
- W2567540060 cites W2139340707 @default.
- W2567540060 cites W2144926703 @default.
- W2567540060 cites W2147577544 @default.
- W2567540060 cites W2148687162 @default.
- W2567540060 cites W2152376449 @default.
- W2567540060 cites W2157725417 @default.
- W2567540060 cites W2165461707 @default.
- W2567540060 cites W2166471379 @default.
- W2567540060 cites W2173748134 @default.
- W2567540060 cites W2193122629 @default.
- W2567540060 cites W2237053569 @default.
- W2567540060 cites W2283777553 @default.
- W2567540060 cites W4211259944 @default.
- W2567540060 cites W4213141530 @default.
- W2567540060 doi "https://doi.org/10.1016/j.rvsc.2016.12.007" @default.
- W2567540060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28043010" @default.
- W2567540060 hasPublicationYear "2017" @default.
- W2567540060 type Work @default.
- W2567540060 sameAs 2567540060 @default.
- W2567540060 citedByCount "22" @default.
- W2567540060 countsByYear W25675400602018 @default.
- W2567540060 countsByYear W25675400602019 @default.
- W2567540060 countsByYear W25675400602020 @default.
- W2567540060 countsByYear W25675400602021 @default.
- W2567540060 countsByYear W25675400602022 @default.
- W2567540060 countsByYear W25675400602023 @default.
- W2567540060 crossrefType "journal-article" @default.
- W2567540060 hasAuthorship W2567540060A5033309555 @default.
- W2567540060 hasAuthorship W2567540060A5045767657 @default.
- W2567540060 hasAuthorship W2567540060A5050199543 @default.
- W2567540060 hasAuthorship W2567540060A5062559507 @default.
- W2567540060 hasAuthorship W2567540060A5066231460 @default.
- W2567540060 hasAuthorship W2567540060A5074707535 @default.
- W2567540060 hasAuthorship W2567540060A5091068751 @default.
- W2567540060 hasConcept C106358424 @default.
- W2567540060 hasConcept C140704245 @default.
- W2567540060 hasConcept C1491633281 @default.
- W2567540060 hasConcept C153911025 @default.
- W2567540060 hasConcept C159047783 @default.
- W2567540060 hasConcept C171779818 @default.
- W2567540060 hasConcept C195687474 @default.
- W2567540060 hasConcept C2522874641 @default.
- W2567540060 hasConcept C2779141303 @default.
- W2567540060 hasConcept C2780568436 @default.
- W2567540060 hasConcept C54355233 @default.