Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567668812> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2567668812 abstract "Therapeutic hypothermia as employed during transplantation, surgery or trauma unavoidably leads to organ damage due to ischemia/reperfusion injury (IRI). Interestingly, hibernating mammals have solved this problem, as they manage to periodically lower their metabolism and body temperature during periods referred to as torpor. Torpor periods are regularly intersected by brief periods (‘arousals’), during which these parameters are restored without organ damage. Several adaptive physiological mechanisms in hibernators may underlie this resistance to organ damage during these period of physiological extremes. We recently identified a reversible remodeling of lung tissue in hibernating Syrian hamsters with regulation of the H2S-producing enzyme, cystathionine-β-synthase (CBS) as one of the adaptive mechanisms. Therefore, this PhD aimed at investigating mechanisms that confer resistance to hypothermia/rewarming with a focus on the role of endogenous hydrogen sulfide gas (H2S) and its synthesizing enzymes in the kidney, representing an organ highly susceptible to hypothermic damage. Main findings are that torpid animals show an upregulation of H2S-synthesizing enzymes and increased blood H2S level. Further, pharmacological inhibition of the H2S-synthesizing pathways prevented entrance into torpor and induced renal injury. Together, this suggests that the H2S pathway is essential not only in inducing hibernation but also in protecting the kidney during these temperature extremes. Further, we found that pharmacological induction of H2S formation by dopamine also protected from kidney damage in rats subjected to forced hypothermia/rewarming. Therefore, maintenance or upregulation of endogenous H2S-synthesizing pathways may offer a novel therapeutic approach in preventing renal IRI associated with clinical conditions which require cooling/rewarming." @default.
- W2567668812 created "2017-01-06" @default.
- W2567668812 creator A5028010297 @default.
- W2567668812 date "2015-01-01" @default.
- W2567668812 modified "2023-09-24" @default.
- W2567668812 title "The role of endogenous H2S production during hibernation and forced hypothermia: towards safe cooling and rewarming in clinical practice" @default.
- W2567668812 hasPublicationYear "2015" @default.
- W2567668812 type Work @default.
- W2567668812 sameAs 2567668812 @default.
- W2567668812 citedByCount "0" @default.
- W2567668812 crossrefType "journal-article" @default.
- W2567668812 hasAuthorship W2567668812A5028010297 @default.
- W2567668812 hasConcept C100564792 @default.
- W2567668812 hasConcept C104317684 @default.
- W2567668812 hasConcept C11413529 @default.
- W2567668812 hasConcept C119865680 @default.
- W2567668812 hasConcept C126322002 @default.
- W2567668812 hasConcept C127561419 @default.
- W2567668812 hasConcept C16613235 @default.
- W2567668812 hasConcept C2777390192 @default.
- W2567668812 hasConcept C2780091579 @default.
- W2567668812 hasConcept C41008148 @default.
- W2567668812 hasConcept C42219234 @default.
- W2567668812 hasConcept C48103436 @default.
- W2567668812 hasConcept C541997718 @default.
- W2567668812 hasConcept C55493867 @default.
- W2567668812 hasConcept C66538056 @default.
- W2567668812 hasConcept C71924100 @default.
- W2567668812 hasConcept C86803240 @default.
- W2567668812 hasConceptScore W2567668812C100564792 @default.
- W2567668812 hasConceptScore W2567668812C104317684 @default.
- W2567668812 hasConceptScore W2567668812C11413529 @default.
- W2567668812 hasConceptScore W2567668812C119865680 @default.
- W2567668812 hasConceptScore W2567668812C126322002 @default.
- W2567668812 hasConceptScore W2567668812C127561419 @default.
- W2567668812 hasConceptScore W2567668812C16613235 @default.
- W2567668812 hasConceptScore W2567668812C2777390192 @default.
- W2567668812 hasConceptScore W2567668812C2780091579 @default.
- W2567668812 hasConceptScore W2567668812C41008148 @default.
- W2567668812 hasConceptScore W2567668812C42219234 @default.
- W2567668812 hasConceptScore W2567668812C48103436 @default.
- W2567668812 hasConceptScore W2567668812C541997718 @default.
- W2567668812 hasConceptScore W2567668812C55493867 @default.
- W2567668812 hasConceptScore W2567668812C66538056 @default.
- W2567668812 hasConceptScore W2567668812C71924100 @default.
- W2567668812 hasConceptScore W2567668812C86803240 @default.
- W2567668812 hasLocation W25676688121 @default.
- W2567668812 hasOpenAccess W2567668812 @default.
- W2567668812 hasPrimaryLocation W25676688121 @default.
- W2567668812 hasRelatedWork W1584067637 @default.
- W2567668812 hasRelatedWork W182505284 @default.
- W2567668812 hasRelatedWork W1912491919 @default.
- W2567668812 hasRelatedWork W1981680164 @default.
- W2567668812 hasRelatedWork W2037178948 @default.
- W2567668812 hasRelatedWork W2037581231 @default.
- W2567668812 hasRelatedWork W2068529705 @default.
- W2567668812 hasRelatedWork W2074054536 @default.
- W2567668812 hasRelatedWork W2144303480 @default.
- W2567668812 hasRelatedWork W2187751337 @default.
- W2567668812 hasRelatedWork W2412509094 @default.
- W2567668812 hasRelatedWork W2602480535 @default.
- W2567668812 hasRelatedWork W2801996683 @default.
- W2567668812 hasRelatedWork W2935864440 @default.
- W2567668812 hasRelatedWork W3024163718 @default.
- W2567668812 hasRelatedWork W3034638523 @default.
- W2567668812 hasRelatedWork W3118440635 @default.
- W2567668812 hasRelatedWork W3173164501 @default.
- W2567668812 hasRelatedWork W613318257 @default.
- W2567668812 hasRelatedWork W633649227 @default.
- W2567668812 isParatext "false" @default.
- W2567668812 isRetracted "false" @default.
- W2567668812 magId "2567668812" @default.
- W2567668812 workType "article" @default.