Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567687811> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2567687811 abstract "Background: Increased levels of Growth Differentiation factor-15 (GDF-15) are associated with cancer related cachexia, cardiovascular disease and all-cause mortality. Its role in COPD is unknown.Methods: The study included 413 patients with COPD from the Bergen COPD Cohort study, aged 41-76. All patients had a FEV1<80% predicted, FEV1/FVC ratio<0.7, and smoking history of more than 10 packyrs. Spirometry, fat free mass index (FFMI), blood gases and plasma levels of GDF-15 were all measured at baseline. The patients were followed for 3 years regarding exacerbations and change in FFMI, and 5 years for mortality. Associations between GDF-15 and FFMI were evaluated with a linear regression model, adjusting for age, sex, smoking, FEV1, yearly exacerbation rate before inclusion, Charlson Comorbidity Score and hypoxemia. For the evaluation of yearly exacerbation rate and survival, a negative binomial regression model and a cox-regression model, respectively, was fitted, adjusting for the same variables.Results: Median plasma GDF-15 was 0.86ng/mL (IQR 0.48). The distribution was not normal, and the variable was dichotomized in high and low values, cut-off median. We found a significant association between high values of GDF-15 and FFMI, coefficient -1.19 (p<0.001) and -0.88 (p=0.001), unadjusted and adjusted values respectively. Similarly, high values of GDF-15 was associated with a higher yearly exacerbation rate, IRR 1.64 (p<0.001) and 1.39 (0.006). Furthermore, high levels of GDF-15 predicted mortality, HR 3.53 (p<0.001) and 1.99 (p=0.02).Conclusion: In COPD-patients, high levels of GDF-15 was independently associated with declining FFMI, higher yearly rate of exacerbations, and higher mortality." @default.
- W2567687811 created "2017-01-06" @default.
- W2567687811 creator A5019052465 @default.
- W2567687811 creator A5021026849 @default.
- W2567687811 creator A5023947673 @default.
- W2567687811 creator A5038135665 @default.
- W2567687811 creator A5052796561 @default.
- W2567687811 creator A5071976053 @default.
- W2567687811 date "2015-09-01" @default.
- W2567687811 modified "2023-10-18" @default.
- W2567687811 title "Growth differentiation factor-15 is a predictor for COPD exacerbations and survival" @default.
- W2567687811 doi "https://doi.org/10.1183/13993003.congress-2015.pa623" @default.
- W2567687811 hasPublicationYear "2015" @default.
- W2567687811 type Work @default.
- W2567687811 sameAs 2567687811 @default.
- W2567687811 citedByCount "0" @default.
- W2567687811 crossrefType "proceedings-article" @default.
- W2567687811 hasAuthorship W2567687811A5019052465 @default.
- W2567687811 hasAuthorship W2567687811A5021026849 @default.
- W2567687811 hasAuthorship W2567687811A5023947673 @default.
- W2567687811 hasAuthorship W2567687811A5038135665 @default.
- W2567687811 hasAuthorship W2567687811A5052796561 @default.
- W2567687811 hasAuthorship W2567687811A5071976053 @default.
- W2567687811 hasConcept C126322002 @default.
- W2567687811 hasConcept C136935669 @default.
- W2567687811 hasConcept C207103383 @default.
- W2567687811 hasConcept C2776780178 @default.
- W2567687811 hasConcept C2777014857 @default.
- W2567687811 hasConcept C44249647 @default.
- W2567687811 hasConcept C50382708 @default.
- W2567687811 hasConcept C71924100 @default.
- W2567687811 hasConcept C72563966 @default.
- W2567687811 hasConceptScore W2567687811C126322002 @default.
- W2567687811 hasConceptScore W2567687811C136935669 @default.
- W2567687811 hasConceptScore W2567687811C207103383 @default.
- W2567687811 hasConceptScore W2567687811C2776780178 @default.
- W2567687811 hasConceptScore W2567687811C2777014857 @default.
- W2567687811 hasConceptScore W2567687811C44249647 @default.
- W2567687811 hasConceptScore W2567687811C50382708 @default.
- W2567687811 hasConceptScore W2567687811C71924100 @default.
- W2567687811 hasConceptScore W2567687811C72563966 @default.
- W2567687811 hasLocation W25676878111 @default.
- W2567687811 hasOpenAccess W2567687811 @default.
- W2567687811 hasPrimaryLocation W25676878111 @default.
- W2567687811 hasRelatedWork W1667184712 @default.
- W2567687811 hasRelatedWork W1912735560 @default.
- W2567687811 hasRelatedWork W1919572160 @default.
- W2567687811 hasRelatedWork W2010151747 @default.
- W2567687811 hasRelatedWork W2014958679 @default.
- W2567687811 hasRelatedWork W2117931062 @default.
- W2567687811 hasRelatedWork W2323447728 @default.
- W2567687811 hasRelatedWork W2328281949 @default.
- W2567687811 hasRelatedWork W2351348722 @default.
- W2567687811 hasRelatedWork W2386603555 @default.
- W2567687811 hasRelatedWork W2409426849 @default.
- W2567687811 hasRelatedWork W2555046500 @default.
- W2567687811 hasRelatedWork W2564962265 @default.
- W2567687811 hasRelatedWork W2583741852 @default.
- W2567687811 hasRelatedWork W2906104191 @default.
- W2567687811 hasRelatedWork W2945953177 @default.
- W2567687811 hasRelatedWork W2989956555 @default.
- W2567687811 hasRelatedWork W1859191341 @default.
- W2567687811 hasRelatedWork W2405777922 @default.
- W2567687811 hasRelatedWork W2517655858 @default.
- W2567687811 isParatext "false" @default.
- W2567687811 isRetracted "false" @default.
- W2567687811 magId "2567687811" @default.
- W2567687811 workType "article" @default.