FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567699103> ?p ?o ?g. }

• W2567699103 endingPage "148" @default.
• W2567699103 startingPage "137" @default.
• W2567699103 abstract "Background In end-stage renal disease (ESRD), coronary artery calcification (CAC) and inflammation contribute to cardiovascular disease (CVD). Statins do not improve survival in patients with ESRD, and their effect on vascular calcification is unclear. We explored associations between CAC, inflammatory biomarkers, statins and mortality in ESRD. Materials and methods In 240 patients with ESRD (63% males; median age 56 years) from cohorts including 86 recipients of living donor kidney transplant (LD-Rtx), 96 incident dialysis patients and 58 prevalent peritoneal dialysis patients, associations of CAC score (Agatston Units, AUs), interleukin-6 (IL-6) with high-sensitivity C-reactive protein (hsCRP), tumour necrosis factor (TNF), use of statins and all-cause mortality were analysed. Cardiac CT was repeated in 35 patients after 1·5 years of renal replacement therapy. In vitro, human vascular smooth muscle cells (hVSMCs) were used to measure vitamin K metabolism. Results Among 240 patients, 129 (53%) had a CAC score > 100 AUs. Multivariate analysis revealed that independent predictors of 1-SD higher CAC score were age, male gender, diabetes and use of statins. The association between CAC score and mortality remained significant after adjustment for age, gender, diabetes, CVD, use of statins, protein-energy wasting and inflammation. Repeated CAC imaging in 35 patients showed that statin therapy was associated with greater progression of CAC. In vitro synthesis of menaquinone-4 by hVSMCs was significantly impaired by statins. Conclusion Elevated CAC score is a mortality risk factor in ESRD independent of inflammation. Future studies should resolve if statins promote vascular calcification and inhibition of vitamin K synthesis in the uremic milieu." @default.
• W2567699103 created "2017-01-06" @default.
• W2567699103 creator A5010560332 @default.
• W2567699103 creator A5021785513 @default.
• W2567699103 creator A5039627768 @default.
• W2567699103 creator A5039987256 @default.
• W2567699103 creator A5044990060 @default.
• W2567699103 creator A5045807220 @default.
• W2567699103 creator A5047447621 @default.
• W2567699103 creator A5054816073 @default.
• W2567699103 creator A5060112092 @default.
• W2567699103 creator A5062830660 @default.
• W2567699103 creator A5070811893 @default.
• W2567699103 creator A5085016255 @default.
• W2567699103 date "2017-01-28" @default.
• W2567699103 modified "2023-10-13" @default.
• W2567699103 title "Does statins promote vascular calcification in chronic kidney disease?" @default.
• W2567699103 cites W1130512620 @default.
• W2567699103 cites W1270175867 @default.
• W2567699103 cites W1512148154 @default.
• W2567699103 cites W1601708437 @default.
• W2567699103 cites W1883824268 @default.
• W2567699103 cites W1969678022 @default.
• W2567699103 cites W1974426737 @default.
• W2567699103 cites W1983022133 @default.
• W2567699103 cites W1994114763 @default.
• W2567699103 cites W1999264494 @default.
• W2567699103 cites W2000313374 @default.
• W2567699103 cites W2002109139 @default.
• W2567699103 cites W2006001326 @default.
• W2567699103 cites W2009602476 @default.
• W2567699103 cites W2009810030 @default.
• W2567699103 cites W2014951154 @default.
• W2567699103 cites W2016232050 @default.
• W2567699103 cites W2020125823 @default.
• W2567699103 cites W2020504510 @default.
• W2567699103 cites W2023653442 @default.
• W2567699103 cites W2029491276 @default.
• W2567699103 cites W2035864756 @default.
• W2567699103 cites W2039421413 @default.
• W2567699103 cites W2050277287 @default.
• W2567699103 cites W2052034325 @default.
• W2567699103 cites W2053437995 @default.
• W2567699103 cites W2055093326 @default.
• W2567699103 cites W2063773732 @default.
• W2567699103 cites W2068801147 @default.
• W2567699103 cites W2068949553 @default.
• W2567699103 cites W2078097737 @default.
• W2567699103 cites W2078499210 @default.
• W2567699103 cites W2080846816 @default.
• W2567699103 cites W2083847691 @default.
• W2567699103 cites W2085051977 @default.
• W2567699103 cites W2094941678 @default.
• W2567699103 cites W2095903478 @default.
• W2567699103 cites W2096978392 @default.
• W2567699103 cites W2109348687 @default.
• W2567699103 cites W2110601215 @default.
• W2567699103 cites W2114164409 @default.
• W2567699103 cites W2120166750 @default.
• W2567699103 cites W2121363804 @default.
• W2567699103 cites W2126340048 @default.
• W2567699103 cites W2129352623 @default.
• W2567699103 cites W2130304988 @default.
• W2567699103 cites W2134120087 @default.
• W2567699103 cites W2136208974 @default.
• W2567699103 cites W2142724975 @default.
• W2567699103 cites W2148145761 @default.
• W2567699103 cites W2149378542 @default.
• W2567699103 cites W2149622957 @default.
• W2567699103 cites W2151301696 @default.
• W2567699103 cites W2152893857 @default.
• W2567699103 cites W2153785016 @default.
• W2567699103 cites W2157125602 @default.
• W2567699103 cites W2161924597 @default.
• W2567699103 cites W2162430779 @default.
• W2567699103 cites W2165853103 @default.
• W2567699103 cites W2185522313 @default.
• W2567699103 cites W2187116586 @default.
• W2567699103 cites W2200002157 @default.
• W2567699103 cites W2324841714 @default.
• W2567699103 cites W2328615536 @default.
• W2567699103 cites W2519695367 @default.
• W2567699103 cites W2555202265 @default.
• W2567699103 cites W4238015229 @default.
• W2567699103 doi "https://doi.org/10.1111/eci.12718" @default.
• W2567699103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28036114" @default.
• W2567699103 hasPublicationYear "2017" @default.
• W2567699103 type Work @default.
• W2567699103 sameAs 2567699103 @default.
• W2567699103 citedByCount "57" @default.
• W2567699103 countsByYear W25676991032017 @default.
• W2567699103 countsByYear W25676991032018 @default.
• W2567699103 countsByYear W25676991032019 @default.
• W2567699103 countsByYear W25676991032020 @default.
• W2567699103 countsByYear W25676991032021 @default.
• W2567699103 countsByYear W25676991032022 @default.
• W2567699103 countsByYear W25676991032023 @default.
• W2567699103 crossrefType "journal-article" @default.

• next