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- W2567701587 abstract "A17 We hypothesized that age-specific incidence rates for breast cancers categorized by aggressiveness would provide important insights into the etiology of racial disparities in incidence. Incidence data are independent of population structure, and facilitate identification of trends not possible with case-case analyses. Using state cancer registry and population data for 1996-2004, restricted to African-American (AA) and European-American (EA) women, we compared age-specific incidence patterns of invasive female breast cancer in South Carolina (a southern, mostly rural population) and Ohio (a northern, more urbanized, more racially and ethnically diverse population). Each case was categorized by estrogen receptor expression status (ER negative (ER-) versus positive (ER+)) and histologic grade (G1 = low grade, G2 = intermediate, G3 = high grade), with ER-/G3 disease the most aggressive. Missing ER and grade data were imputed using state, age and race-specific distributions of known grade and ER. Age-specific incidence patterns were modeled using Poisson regression, where predictors were age and stage, plus race, ER status and grade, and, as appropriate, interaction variables. Rates for each ER/Grade combination were age-adjusted to the 2000 US standard population. Distinct age-specific incidence patterns were found for each ER/Grade group, with several striking differences by race. EA women had a substantial excess incidence of both ER+/G1 and ER+/G2 cancers (combined, 75% higher than AA women in SC, 44% in Ohio), primarily in post-menopausal years. Conversely, AA women had a substantially higher incidence of ER-/G3 cancer (63% in SC, and 67% in Ohio). Racial differences in rates by ER/Grade were fairly constant between ages 30 and 65 years. In both races, regardless of grade, the incidence ratio of ER- cancer (versus ER+) peaked at about age 35. Comparing Ohio to SC, rates in EA women were extremely similar for each ER/Grade group. Rates in AA women also varied little between States, notably except ER+/G1 and ER+/G2 cancers which combined had a 28% higher rate in Ohio; State differences in AA ER-/G3 rates were" @default.
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- W2567701587 date "2007-11-01" @default.
- W2567701587 modified "2023-09-23" @default.
- W2567701587 title "Racial disparities in breast cancer age-specific incidence rates suggest risk factors interact to cause elevated rates of high grade estrogen receptor negative disease, especially in African American women" @default.
- W2567701587 hasPublicationYear "2007" @default.
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