Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567721878> ?p ?o ?g. }
- W2567721878 endingPage "730" @default.
- W2567721878 startingPage "724" @default.
- W2567721878 abstract "The majority of aluminum phosphide (ALP) toxicity cases are suicidal attempts. Despite advances in critical care medicine, the mortality rate of ALP remains very high. Unfortunately, knowledge on the toxicokinetics of ALP is very low. An obsolete idea was proposed that inhibition of complex IV of cytochrome C oxidase is responsible for multiorgan dysfunction. However, based on human studies, this effect might be insignificant. Thus, a novel idea proposes that the main mechanism might be vascular wall integrity disruption. The low frequency of acute toxicity and unanswered questions about the toxicokinetics and toxicodynamics has led to leaden advances of novel treatments. The aim of this review was to evaluate problems regarding current treatment protocols and propose new ideas based on updated information. For this purpose, we reviewed all available articles on the management of ALP poisoning published to date. Considering failure of conventional therapies on maintaining systolic blood pressure, correcting acid-base disturbances, and support cardiac function, the previous treatment protocols have been overruled. However, repudiate of conventional treatments in this deadly condition is not without penalties for the health-care provider. The introduction of new therapies including refuse of gastric lavage with water-soluble compounds, administration of a high molecular weight colloidal solution for fluid resuscitation and termination using sodium bicarbonate, and vasoactive agents has been prospected to improve patient survival. This protocol is in early clinical evaluation; nevertheless, it appears to improve patient's survival; hence, future randomized trials should be performed to support their effectiveness." @default.
- W2567721878 created "2017-01-06" @default.
- W2567721878 creator A5010026632 @default.
- W2567721878 creator A5070350245 @default.
- W2567721878 creator A5085169748 @default.
- W2567721878 date "2016-01-01" @default.
- W2567721878 modified "2023-10-16" @default.
- W2567721878 title "Thoughts on the current management of acute aluminum phosphide toxicity and proposals for therapy: An Evidence-based review" @default.
- W2567721878 cites W118154668 @default.
- W2567721878 cites W125309264 @default.
- W2567721878 cites W126832887 @default.
- W2567721878 cites W1484486237 @default.
- W2567721878 cites W173397218 @default.
- W2567721878 cites W1920185087 @default.
- W2567721878 cites W1924561487 @default.
- W2567721878 cites W1963743101 @default.
- W2567721878 cites W1965031906 @default.
- W2567721878 cites W1966047225 @default.
- W2567721878 cites W1975470385 @default.
- W2567721878 cites W1990024744 @default.
- W2567721878 cites W1994142720 @default.
- W2567721878 cites W2001988357 @default.
- W2567721878 cites W2002114892 @default.
- W2567721878 cites W2003906278 @default.
- W2567721878 cites W2008833242 @default.
- W2567721878 cites W2013126781 @default.
- W2567721878 cites W2020797956 @default.
- W2567721878 cites W2021509793 @default.
- W2567721878 cites W2029078679 @default.
- W2567721878 cites W2033091944 @default.
- W2567721878 cites W2034954531 @default.
- W2567721878 cites W2036573181 @default.
- W2567721878 cites W2036778165 @default.
- W2567721878 cites W2037053186 @default.
- W2567721878 cites W2045024343 @default.
- W2567721878 cites W2054691599 @default.
- W2567721878 cites W2056723096 @default.
- W2567721878 cites W2059044841 @default.
- W2567721878 cites W2075672990 @default.
- W2567721878 cites W2079784018 @default.
- W2567721878 cites W2081384482 @default.
- W2567721878 cites W2092492602 @default.
- W2567721878 cites W2095517235 @default.
- W2567721878 cites W2103551906 @default.
- W2567721878 cites W2104320079 @default.
- W2567721878 cites W2112724479 @default.
- W2567721878 cites W2117450126 @default.
- W2567721878 cites W2122166353 @default.
- W2567721878 cites W2128051473 @default.
- W2567721878 cites W2129468367 @default.
- W2567721878 cites W2131600441 @default.
- W2567721878 cites W2131779114 @default.
- W2567721878 cites W2135462156 @default.
- W2567721878 cites W2139408713 @default.
- W2567721878 cites W2140182103 @default.
- W2567721878 cites W2144314803 @default.
- W2567721878 cites W2151517168 @default.
- W2567721878 cites W2167143237 @default.
- W2567721878 cites W2169977603 @default.
- W2567721878 cites W2262522532 @default.
- W2567721878 cites W2278726552 @default.
- W2567721878 cites W2317791088 @default.
- W2567721878 cites W2322306791 @default.
- W2567721878 cites W2334471721 @default.
- W2567721878 cites W2405575827 @default.
- W2567721878 cites W2413565419 @default.
- W2567721878 cites W2414561920 @default.
- W2567721878 cites W2416214192 @default.
- W2567721878 cites W2418550419 @default.
- W2567721878 cites W2463114649 @default.
- W2567721878 cites W2468876760 @default.
- W2567721878 cites W2469598333 @default.
- W2567721878 cites W2530385243 @default.
- W2567721878 cites W2566512592 @default.
- W2567721878 cites W2618116161 @default.
- W2567721878 cites W26385428 @default.
- W2567721878 cites W26701610 @default.
- W2567721878 cites W307106421 @default.
- W2567721878 cites W4251526541 @default.
- W2567721878 cites W56550838 @default.
- W2567721878 cites W7000606 @default.
- W2567721878 doi "https://doi.org/10.4103/0972-5229.195712" @default.
- W2567721878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5225774" @default.
- W2567721878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28149031" @default.
- W2567721878 hasPublicationYear "2016" @default.
- W2567721878 type Work @default.
- W2567721878 sameAs 2567721878 @default.
- W2567721878 citedByCount "25" @default.
- W2567721878 countsByYear W25677218782017 @default.
- W2567721878 countsByYear W25677218782018 @default.
- W2567721878 countsByYear W25677218782019 @default.
- W2567721878 countsByYear W25677218782020 @default.
- W2567721878 countsByYear W25677218782021 @default.
- W2567721878 countsByYear W25677218782022 @default.
- W2567721878 countsByYear W25677218782023 @default.
- W2567721878 crossrefType "journal-article" @default.
- W2567721878 hasAuthorship W2567721878A5010026632 @default.
- W2567721878 hasAuthorship W2567721878A5070350245 @default.