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- W2567730078 abstract "Objective:To characterize the clinical profiles of Alzheimer’s disease(AD) patients with psychotic symptoms, delineated into those with delusions, hallucinations, or both.Background:It is estimated that 41[percnt] of AD patients develop psychosis over the course of the illness, 1/3 presenting with delusions and 1/6 with hallucinations. Psychosis in AD is associated with increased cognitive and functional decline, and a more rapid disease progression.Design/Methods:728 subjects from the NACC database with pathologically confirmed AD diagnosis were analyzed. The NPI-Q was used to identify subjects with psychosis and the type of psychosis. Psychotic subjects(AD+P) and each of its subgroups(delusions: AD+D; hallucinations: AD+H; delusions and hallucinations: AD+DH) were compared to never-psychotic subjects(AD-P) using univariate tests, α=0.05.Results:There were no significant differences between AD-P(n=457) and AD+P(n=271) subjects with respect to age of death, years of education, ethnicity, sex, or functional(FAQ) and cognitive status(MMSE, CDR) at the last visit before death. AD+P had a significantly longer disease duration calculated from age of clinical onset to age of death. Breakdown by psychotic symptoms showed that subjects with hallucinations(AD+H(n=52); AD+DH(n=79)) had increased cognitive and functional impairment while delusional subjects(AD+D,n=140) were less cognitively impaired than AD-P. The increased duration of disease was restricted to delusional subjects(AD+D and AD+DH).Conclusion:The contrast between AD patients who experienced delusions versus hallucinations has not been previously reported. Subjects with hallucinations had lower cognitive and functional status compared to non-psychotic subjects, while subjects with delusions had better cognitive status. A possible explanation is that expression of delusions requires some level of cognitive ability, and that delusions diminish with cognition. Data also show that psychotic subjects in general, and those with delusions in particular, had a slower disease progression, contrary to some literature. The distressing nature of psychotic symptoms may prompt these patients to seek medical attention earlier, creating artificially longer disease duration. Disclosure: Dr. Qian has nothing to disclose. Dr. Fischer has nothing to disclose. Dr. Schweizer has nothing to disclose. Dr. Munoz has nothing to disclose." @default.
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- W2567730078 date "2016-04-05" @default.
- W2567730078 modified "2023-09-27" @default.
- W2567730078 title "Cognitive and Functional Differences Between Delusions and Hallucinations in Alzheimer’s Disease (P2.234)" @default.
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