FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567746986> ?p ?o ?g. }

• W2567746986 abstract "Abstract Current guidelines lack comprehensive information on the metastatic site-specific role of KRAS mutation in lung adenocarcinoma (LADC). We investigated the effect of KRAS mutation on overall survival (OS) in this setting. In our retrospective study, 500 consecutive Caucasian metastatic LADC patients with known KRAS mutational status were analyzed after excluding 32 patients with EGFR mutations. KRAS mutation incidence was 28.6%. The most frequent metastatic sites were lung (45.6%), bone (26.2%), adrenal gland (17.4%), brain (16.8%), pleura (15.6%) and liver (11%). Patients with intrapulmonary metastasis had significantly increased KRAS mutation frequency compared to those with extrapulmonary metastases (35% vs 26.5%, p = 0.0125). In contrast, pleural dissemination and liver involvement were associated with significantly decreased KRAS mutation incidence (vs all other metastatic sites; 17% (p < 0.001) and 16% (p = 0.02) vs 33%, respectively). Strikingly, we found a significant prognostic effect of KRAS status only in the bone metastatic subcohort (KRAS-wild-type vs KRAS-mutant; median OS 9.7 v 3.7 months; HR, 0.49; 95% CI, 0.31 to 0.79; p = 0.003). Our study suggests that KRAS mutation frequency in LADC patients shows a metastatic site dependent variation and, moreover, that the presence of KRAS mutation is associated with significantly worse outcome in bone metastatic cases." @default.
• W2567746986 created "2017-01-13" @default.
• W2567746986 creator A5007718548 @default.
• W2567746986 creator A5018388032 @default.
• W2567746986 creator A5028746264 @default.
• W2567746986 creator A5029992691 @default.
• W2567746986 creator A5032882550 @default.
• W2567746986 creator A5049740628 @default.
• W2567746986 creator A5050703928 @default.
• W2567746986 creator A5057244028 @default.
• W2567746986 creator A5061479988 @default.
• W2567746986 creator A5066209110 @default.
• W2567746986 creator A5067140213 @default.
• W2567746986 creator A5082305389 @default.
• W2567746986 creator A5086393240 @default.
• W2567746986 creator A5088138638 @default.
• W2567746986 date "2017-01-04" @default.
• W2567746986 modified "2023-10-18" @default.
• W2567746986 title "KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: poor prognosis in patients with KRAS mutation and bone metastasis" @default.
• W2567746986 cites W1492286179 @default.
• W2567746986 cites W1531159584 @default.
• W2567746986 cites W1710915557 @default.
• W2567746986 cites W1712727770 @default.
• W2567746986 cites W1964869313 @default.
• W2567746986 cites W1974662648 @default.
• W2567746986 cites W1989595177 @default.
• W2567746986 cites W1991874467 @default.
• W2567746986 cites W2014449122 @default.
• W2567746986 cites W2028480941 @default.
• W2567746986 cites W2029908992 @default.
• W2567746986 cites W2030485399 @default.
• W2567746986 cites W2031570350 @default.
• W2567746986 cites W2035390137 @default.
• W2567746986 cites W2036336666 @default.
• W2567746986 cites W2037475133 @default.
• W2567746986 cites W2049723491 @default.
• W2567746986 cites W2052820539 @default.
• W2567746986 cites W2057209504 @default.
• W2567746986 cites W2066347437 @default.
• W2567746986 cites W2067240437 @default.
• W2567746986 cites W2068423195 @default.
• W2567746986 cites W2070247319 @default.
• W2567746986 cites W2076204388 @default.
• W2567746986 cites W2088720324 @default.
• W2567746986 cites W2092657105 @default.
• W2567746986 cites W2099788868 @default.
• W2567746986 cites W2111625845 @default.
• W2567746986 cites W2120420501 @default.
• W2567746986 cites W2121869934 @default.
• W2567746986 cites W2122036613 @default.
• W2567746986 cites W2135184154 @default.
• W2567746986 cites W2142850084 @default.
• W2567746986 cites W2151660493 @default.
• W2567746986 cites W2159517121 @default.
• W2567746986 cites W2159594827 @default.
• W2567746986 cites W2159948812 @default.
• W2567746986 cites W2161516303 @default.
• W2567746986 cites W2168161641 @default.
• W2567746986 cites W2189564664 @default.
• W2567746986 cites W2219662516 @default.
• W2567746986 cites W2225497209 @default.
• W2567746986 cites W2239964025 @default.
• W2567746986 cites W2271051170 @default.
• W2567746986 cites W2314718805 @default.
• W2567746986 cites W2315546388 @default.
• W2567746986 cites W2337358073 @default.
• W2567746986 cites W2514360855 @default.
• W2567746986 cites W2890066506 @default.
• W2567746986 cites W613049427 @default.
• W2567746986 doi "https://doi.org/10.1038/srep39721" @default.
• W2567746986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5209707" @default.
• W2567746986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28051122" @default.
• W2567746986 hasPublicationYear "2017" @default.
• W2567746986 type Work @default.
• W2567746986 sameAs 2567746986 @default.
• W2567746986 citedByCount "56" @default.
• W2567746986 countsByYear W25677469862016 @default.
• W2567746986 countsByYear W25677469862017 @default.
• W2567746986 countsByYear W25677469862018 @default.
• W2567746986 countsByYear W25677469862019 @default.
• W2567746986 countsByYear W25677469862020 @default.
• W2567746986 countsByYear W25677469862021 @default.
• W2567746986 countsByYear W25677469862022 @default.
• W2567746986 countsByYear W25677469862023 @default.
• W2567746986 crossrefType "journal-article" @default.
• W2567746986 hasAuthorship W2567746986A5007718548 @default.
• W2567746986 hasAuthorship W2567746986A5018388032 @default.
• W2567746986 hasAuthorship W2567746986A5028746264 @default.
• W2567746986 hasAuthorship W2567746986A5029992691 @default.
• W2567746986 hasAuthorship W2567746986A5032882550 @default.
• W2567746986 hasAuthorship W2567746986A5049740628 @default.
• W2567746986 hasAuthorship W2567746986A5050703928 @default.
• W2567746986 hasAuthorship W2567746986A5057244028 @default.
• W2567746986 hasAuthorship W2567746986A5061479988 @default.
• W2567746986 hasAuthorship W2567746986A5066209110 @default.
• W2567746986 hasAuthorship W2567746986A5067140213 @default.
• W2567746986 hasAuthorship W2567746986A5082305389 @default.
• W2567746986 hasAuthorship W2567746986A5086393240 @default.
• W2567746986 hasAuthorship W2567746986A5088138638 @default.
• W2567746986 hasBestOaLocation W25677469861 @default.

• next