FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567797464> ?p ?o ?g. }

• W2567797464 abstract "Abstract HLA-C has been demonstrated to associate with HIV-1 envelope glycoprotein (Env). Virions lacking HLA-C have reduced infectivity and increased susceptibility to neutralizing antibodies. Like all others MHC-I molecules, HLA-C requires β 2 -microglobulin (β 2 m) for appropriate folding and expression on the cell membrane but this association is weaker, thus generating HLA-C free-chains on the cell surface. In this study, we deepen the understanding of HLA-C and Env association by showing that HIV-1 specifically increases the amount of HLA-C free chains, not bound to β 2 m, on the membrane of infected cells. The association between Env and HLA-C takes place at the cell membrane requiring β 2 m to occur. We report that the enhanced infectivity conferred to HIV-1 by HLA-C specifically involves HLA-C free chain molecules that have been correctly assembled with β 2 m. HIV-1 Env-pseudotyped viruses produced in the absence of β 2 m are less infectious than those produced in the presence of β 2 m. We hypothesize that the conformation and surface expression of HLA-C molecules could be a discriminant for the association with Env. Binding stability to β 2 m may confer to HLA-C the ability to preferentially act either as a conventional immune-competent molecule or as an accessory molecule involved in HIV-1 infectivity." @default.
• W2567797464 created "2017-01-13" @default.
• W2567797464 creator A5001174531 @default.
• W2567797464 creator A5010698420 @default.
• W2567797464 creator A5032649308 @default.
• W2567797464 creator A5036795668 @default.
• W2567797464 creator A5037379178 @default.
• W2567797464 creator A5039343200 @default.
• W2567797464 creator A5050549426 @default.
• W2567797464 creator A5055628496 @default.
• W2567797464 creator A5064251259 @default.
• W2567797464 creator A5066446008 @default.
• W2567797464 creator A5072998703 @default.
• W2567797464 creator A5074111051 @default.
• W2567797464 creator A5079709625 @default.
• W2567797464 creator A5086296903 @default.
• W2567797464 date "2017-01-04" @default.
• W2567797464 modified "2023-10-14" @default.
• W2567797464 title "HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity" @default.
• W2567797464 cites W1506397040 @default.
• W2567797464 cites W1710945765 @default.
• W2567797464 cites W1961668980 @default.
• W2567797464 cites W1965528983 @default.
• W2567797464 cites W1971434113 @default.
• W2567797464 cites W1973079961 @default.
• W2567797464 cites W1973251432 @default.
• W2567797464 cites W1978699559 @default.
• W2567797464 cites W1986189797 @default.
• W2567797464 cites W1987054851 @default.
• W2567797464 cites W1995626692 @default.
• W2567797464 cites W1995675455 @default.
• W2567797464 cites W1998439550 @default.
• W2567797464 cites W1999152416 @default.
• W2567797464 cites W1999341037 @default.
• W2567797464 cites W2006278700 @default.
• W2567797464 cites W2006839543 @default.
• W2567797464 cites W2007362922 @default.
• W2567797464 cites W2012904796 @default.
• W2567797464 cites W2013729472 @default.
• W2567797464 cites W2017418049 @default.
• W2567797464 cites W2025724570 @default.
• W2567797464 cites W2034577888 @default.
• W2567797464 cites W2037696254 @default.
• W2567797464 cites W2039266996 @default.
• W2567797464 cites W2043541788 @default.
• W2567797464 cites W2045062204 @default.
• W2567797464 cites W2057442177 @default.
• W2567797464 cites W2064085330 @default.
• W2567797464 cites W2065137093 @default.
• W2567797464 cites W2066013797 @default.
• W2567797464 cites W2067036696 @default.
• W2567797464 cites W2072441073 @default.
• W2567797464 cites W2074853522 @default.
• W2567797464 cites W2083448016 @default.
• W2567797464 cites W2088564222 @default.
• W2567797464 cites W2091335989 @default.
• W2567797464 cites W2093922901 @default.
• W2567797464 cites W2099823590 @default.
• W2567797464 cites W2107266668 @default.
• W2567797464 cites W2109066274 @default.
• W2567797464 cites W2113353641 @default.
• W2567797464 cites W2118820599 @default.
• W2567797464 cites W2120687214 @default.
• W2567797464 cites W2123584222 @default.
• W2567797464 cites W2125308808 @default.
• W2567797464 cites W2126255146 @default.
• W2567797464 cites W2126357902 @default.
• W2567797464 cites W2128360359 @default.
• W2567797464 cites W2139257243 @default.
• W2567797464 cites W2146478787 @default.
• W2567797464 cites W2146704167 @default.
• W2567797464 cites W2156429938 @default.
• W2567797464 cites W2167255753 @default.
• W2567797464 cites W2290312132 @default.
• W2567797464 cites W2322220338 @default.
• W2567797464 cites W2371536864 @default.
• W2567797464 cites W2409471903 @default.
• W2567797464 cites W2410069315 @default.
• W2567797464 doi "https://doi.org/10.1038/srep40037" @default.
• W2567797464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5209703" @default.
• W2567797464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28051183" @default.
• W2567797464 hasPublicationYear "2017" @default.
• W2567797464 type Work @default.
• W2567797464 sameAs 2567797464 @default.
• W2567797464 citedByCount "14" @default.
• W2567797464 countsByYear W25677974642017 @default.
• W2567797464 countsByYear W25677974642018 @default.
• W2567797464 countsByYear W25677974642019 @default.
• W2567797464 countsByYear W25677974642020 @default.
• W2567797464 countsByYear W25677974642021 @default.
• W2567797464 countsByYear W25677974642022 @default.
• W2567797464 countsByYear W25677974642023 @default.
• W2567797464 crossrefType "journal-article" @default.
• W2567797464 hasAuthorship W2567797464A5001174531 @default.
• W2567797464 hasAuthorship W2567797464A5010698420 @default.
• W2567797464 hasAuthorship W2567797464A5032649308 @default.
• W2567797464 hasAuthorship W2567797464A5036795668 @default.
• W2567797464 hasAuthorship W2567797464A5037379178 @default.
• W2567797464 hasAuthorship W2567797464A5039343200 @default.
• W2567797464 hasAuthorship W2567797464A5050549426 @default.

• next