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- W2567816974 abstract "The aqueous root extract of Sanseviera liberica Ger, & Labr. (SL) is used in African folklore medicine for ailments including chronic pain and inflammatory conditions, and convulsive disorders [1]. Because of the potential for long term uses, the study investigated the acute and subchronic toxicity patterns of the plant. Acute oral & i.p. toxicity tests were carried out in mice; and the median lethal dose estimated [2]. Subchronic (52 days) studies were conducted in rats with oral daily doses of 80, 400 & 2000mg/kg, which represented 1/ 5 [3], active dose and 5x the pharmacologically active dose [4], respectively. Parameters observed at the end of chronic tests included changes in body & vital organ weights, mortality, haematological, biochemical, hepatic and male reproductive effects [3, 4]. SL did not produce any visible toxicities or mortality with oral doses up to 20g/kg within 14 days of single treatment, but i.p. administration caused mortalities with LD50 of 668.3mg/kg. In the chronic tests, neither mortality nor visible signs of lethality was seen in rats. No significant change in the weight of the kidney, liver, heart and spleen, but at 400mg/kg, a significant reduction in weight of the lungs. Significant increases in the weight of testes, sperm count and motility was produced. There were no changes in the sperm head and tail abnormalities, but significant increases in the % normal sperm cells. Biochemical parameters like the AST, ALT and uric acid were not affected, but significant increase in ALP level at 2g/kg was produced. Significant increase in RBC was recorded, but no changes in levels of PCV and Hb. Results indicate that oral doses of SL are safe, but assessment of hepato-biliary function be done during chronic uses." @default.
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- W2567816974 date "2006-08-24" @default.
- W2567816974 modified "2023-09-26" @default.
- W2567816974 title "Toxicity assessment of the aqueous root extract of Sanseviera Liberica (Agavaceae)" @default.
- W2567816974 doi "https://doi.org/10.1055/s-2006-950120" @default.
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