Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567858933> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2567858933 endingPage "168" @default.
- W2567858933 startingPage "160" @default.
- W2567858933 abstract "Two oleanenes, olean-18(19)-en-3β-yl-(3,6-dimethyl-3E,6Z-dienoate) and (13α)-27-frido-olean-14(15)-en-(17α)-furanyl-3β-ol representing a class of rare natural pentacyclic triterpenoids were isolated from the chloroform extract of Asiatic mangrove, Rhizophora mucronata Lam. (Family: Rhizophoraceae). The furanyl oleanene exhibited significantly greater antioxidative activities (IC50 0.73-0.76 mg/mL), than prenylated oleanene (IC50 0.84-0.96 mg/mL) (P < 0.05). No significant differences in anti-5-lipoxygenase activities of these compounds with the synthetic drug ibuprofen was discernable (IC50 0.8-0.9 mg/mL), whilst furanyl oleanene demonstrated significantly greater anti-cyclooxygenase-2 (IC50 0.84 mg/mL) and anti-5-lipoxygenase activities (IC50 0.78 mg/mL) over prenylated oleanene (IC50 > 0.90 mg/mL). These compounds exhibited lesser activity against cyclooxygenase-1 than cyclooxygenase-2 isoform, and therefore, their selectivity indices remained significantly greater (anti-cyclooxygenase-1IC50/anti-cyclooxygenase-2IC50 > 1) than the aspirin (0.02) and ibuprofen (0.44). The lipophilic and steric molecular descriptors were found to occupy a prominent role in determining the bioactivities of the compounds. These previously undescribed oleanenes might serve as potential antioxidative and anti-inflammatory lead molecules in medicinal formulations and food industries." @default.
- W2567858933 created "2017-01-13" @default.
- W2567858933 creator A5045919562 @default.
- W2567858933 creator A5080423658 @default.
- W2567858933 date "2017-03-01" @default.
- W2567858933 modified "2023-10-14" @default.
- W2567858933 title "Two rare antioxidant and anti-inflammatory oleanenes from loop root Asiatic mangrove Rhizophora mucronata" @default.
- W2567858933 cites W1964497563 @default.
- W2567858933 cites W1978689232 @default.
- W2567858933 cites W1988330336 @default.
- W2567858933 cites W1992365627 @default.
- W2567858933 cites W2003089097 @default.
- W2567858933 cites W2007776162 @default.
- W2567858933 cites W2036856354 @default.
- W2567858933 cites W2042053670 @default.
- W2567858933 cites W2046449147 @default.
- W2567858933 cites W2073397664 @default.
- W2567858933 cites W2085761559 @default.
- W2567858933 cites W2088084304 @default.
- W2567858933 cites W2089850752 @default.
- W2567858933 cites W2090744294 @default.
- W2567858933 cites W2091498869 @default.
- W2567858933 cites W2093701215 @default.
- W2567858933 cites W2093755380 @default.
- W2567858933 cites W2103456976 @default.
- W2567858933 cites W2142157965 @default.
- W2567858933 cites W2143942108 @default.
- W2567858933 cites W2171916359 @default.
- W2567858933 cites W2211962332 @default.
- W2567858933 cites W2313643750 @default.
- W2567858933 cites W2331086861 @default.
- W2567858933 cites W932890253 @default.
- W2567858933 doi "https://doi.org/10.1016/j.phytochem.2016.12.013" @default.
- W2567858933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28062072" @default.
- W2567858933 hasPublicationYear "2017" @default.
- W2567858933 type Work @default.
- W2567858933 sameAs 2567858933 @default.
- W2567858933 citedByCount "17" @default.
- W2567858933 countsByYear W25678589332017 @default.
- W2567858933 countsByYear W25678589332018 @default.
- W2567858933 countsByYear W25678589332019 @default.
- W2567858933 countsByYear W25678589332020 @default.
- W2567858933 countsByYear W25678589332021 @default.
- W2567858933 countsByYear W25678589332022 @default.
- W2567858933 countsByYear W25678589332023 @default.
- W2567858933 crossrefType "journal-article" @default.
- W2567858933 hasAuthorship W2567858933A5045919562 @default.
- W2567858933 hasAuthorship W2567858933A5080423658 @default.
- W2567858933 hasConcept C181199279 @default.
- W2567858933 hasConcept C185592680 @default.
- W2567858933 hasConcept C18903297 @default.
- W2567858933 hasConcept C202751555 @default.
- W2567858933 hasConcept C2777752497 @default.
- W2567858933 hasConcept C2777817122 @default.
- W2567858933 hasConcept C2777912774 @default.
- W2567858933 hasConcept C2779689624 @default.
- W2567858933 hasConcept C2780857362 @default.
- W2567858933 hasConcept C55493867 @default.
- W2567858933 hasConcept C556039675 @default.
- W2567858933 hasConcept C68874143 @default.
- W2567858933 hasConcept C71240020 @default.
- W2567858933 hasConcept C71924100 @default.
- W2567858933 hasConcept C86803240 @default.
- W2567858933 hasConceptScore W2567858933C181199279 @default.
- W2567858933 hasConceptScore W2567858933C185592680 @default.
- W2567858933 hasConceptScore W2567858933C18903297 @default.
- W2567858933 hasConceptScore W2567858933C202751555 @default.
- W2567858933 hasConceptScore W2567858933C2777752497 @default.
- W2567858933 hasConceptScore W2567858933C2777817122 @default.
- W2567858933 hasConceptScore W2567858933C2777912774 @default.
- W2567858933 hasConceptScore W2567858933C2779689624 @default.
- W2567858933 hasConceptScore W2567858933C2780857362 @default.
- W2567858933 hasConceptScore W2567858933C55493867 @default.
- W2567858933 hasConceptScore W2567858933C556039675 @default.
- W2567858933 hasConceptScore W2567858933C68874143 @default.
- W2567858933 hasConceptScore W2567858933C71240020 @default.
- W2567858933 hasConceptScore W2567858933C71924100 @default.
- W2567858933 hasConceptScore W2567858933C86803240 @default.
- W2567858933 hasLocation W25678589331 @default.
- W2567858933 hasLocation W25678589332 @default.
- W2567858933 hasOpenAccess W2567858933 @default.
- W2567858933 hasPrimaryLocation W25678589331 @default.
- W2567858933 hasRelatedWork W1939725092 @default.
- W2567858933 hasRelatedWork W2130774518 @default.
- W2567858933 hasRelatedWork W2187828558 @default.
- W2567858933 hasRelatedWork W2223290449 @default.
- W2567858933 hasRelatedWork W2944735190 @default.
- W2567858933 hasRelatedWork W4231857900 @default.
- W2567858933 hasRelatedWork W4296975494 @default.
- W2567858933 hasRelatedWork W4315645847 @default.
- W2567858933 hasRelatedWork W4319224413 @default.
- W2567858933 hasRelatedWork W4385156315 @default.
- W2567858933 hasVolume "135" @default.
- W2567858933 isParatext "false" @default.
- W2567858933 isRetracted "false" @default.
- W2567858933 magId "2567858933" @default.
- W2567858933 workType "article" @default.