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- W2567874459 abstract "The type 1 cannabinoid receptor, CB 1 , is one of the most abundant G protein coupled receptors (GPCRs) in the human brain, and mediates the psychoactive effects of cannabis. The endocannabinoids (eg, anandamide), phytocannabinoids (eg, Δ 9 -THC), and synthetic cannabinoids (eg, CP55,940, WIN55,212-2) act as agonists at CB 1 , evoking various intracellular signaling responses through receptor activation. Typically, these responses include Gα i/o protein-associated phenotypes such as adenylate cyclase inhibition, and extracellular signal-regulated kinase (ERK) phosphorylation. However, unlike most GPCRs, CB 1 is understood to couple to different G proteins under different conditions, adding to the complexity of cannabinoid signaling characterization. This review summarizes the current understanding of CB 1 receptor signaling, focusing particularly on G protein-mediated signaling, and on the subsequent regulation of the receptor that follows its activation." @default.
- W2567874459 created "2017-01-13" @default.
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- W2567874459 date "2017-01-01" @default.
- W2567874459 modified "2023-10-16" @default.
- W2567874459 title "Signaling and Regulation of the Cannabinoid CB 1 Receptor" @default.
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- W2567874459 doi "https://doi.org/10.1016/b978-0-12-800756-3.00069-7" @default.
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