FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567889801> ?p ?o ?g. }

• W2567889801 endingPage "S691" @default.
• W2567889801 startingPage "S691" @default.
• W2567889801 abstract "The past decade has seen several advances in the field of non-small cell lung cancer (NSCLC), with improved tools for tumor characterization as well as novel targeted and immune therapies. It is important to understand the current treatment landscape including treatment outcomes, in order to maximize patient benefits from these advances. SCAN-LEAF is a Scandinavian retrospective cohort study with prospective annual data cuts, providing a unique opportunity for insights into real-world clinical NSCLC practice over more than a decade. It includes clinical practice patterns of tissue biopsy, pathological diagnosis and tumor biomarker status testing, and their relationship to treatment choices and outcomes. Here, we present intermediate and survival outcomes by disease stage and histology subtype, and factors associated with survival. SCAN-LEAF consists of a registry-based cohort including all diagnosed NSCLC patients in Denmark, Norway and Sweden (Cohort 1), and a Swedish sub-cohort (Cohort 2) supplemented with data from electronic medical records (EMRs). Based on the first data collection including data from NSCLC patients diagnosed 2005-2013, overall survival (OS; Cohort 1 & 2) and progression-free survival (PFS; Cohort 2) will be estimated using Kaplan-Meier analysis and reported as cumulative incidences (with 95% CI) by disease stage at diagnosis, histological subtype, biomarker status, presence of metastases, age and gender. Response rates (Cohort 2) will be described by treatment line in addition to stage and histology subtype. Association of stage with survival (Cohort 1 and 2) and treatment response (Cohort 2) will be analyzed by Cox regression with time to event (death or response) as outcome variable and disease stage category at diagnosis, follow-up time, and therapy line as stratification variables. In addition, the relationship between OS and intermediate outcomes, as well as predictors of OS (e.g. smoking and biomarker status, lesion location, metastasis at diagnosis), will be explored by Cox regression (Cohort 2). Intermediate and survival outcomes for Scandinavian NSCLC patients diagnosed between 2005 and 2013, as well as any association between overall survival and factors such as patient characteristics and treatment patterns, will be presented. The SCAN-LEAF study, expected to include >115,000 Scandinavian NSCLC patients and >2,000 sub-cohort patients diagnosed between 2005 and 2018 during the full duration of the study, will give valuable insights into current care, changing treatment patterns and patient outcomes in a real-world setting. A better understanding of factors associated with survival and intermediate outcomes among NSCLC patients will inform clinical decision-making." @default.
• W2567889801 created "2017-01-13" @default.
• W2567889801 creator A5004368917 @default.
• W2567889801 creator A5010584152 @default.
• W2567889801 creator A5018148458 @default.
• W2567889801 creator A5028019929 @default.
• W2567889801 creator A5034572004 @default.
• W2567889801 creator A5034900588 @default.
• W2567889801 creator A5036382416 @default.
• W2567889801 creator A5048694467 @default.
• W2567889801 creator A5051144449 @default.
• W2567889801 creator A5052417668 @default.
• W2567889801 creator A5068097109 @default.
• W2567889801 creator A5079045120 @default.
• W2567889801 date "2017-01-01" @default.
• W2567889801 modified "2023-10-18" @default.
• W2567889801 title "P1.06-041 Overall Survival and Intermediate Outcomes among Scandinavian Non-Small Cell Lung Cancer Patients: The SCAN-LEAF Study" @default.
• W2567889801 doi "https://doi.org/10.1016/j.jtho.2016.11.905" @default.
• W2567889801 hasPublicationYear "2017" @default.
• W2567889801 type Work @default.
• W2567889801 sameAs 2567889801 @default.
• W2567889801 citedByCount "0" @default.
• W2567889801 crossrefType "journal-article" @default.
• W2567889801 hasAuthorship W2567889801A5004368917 @default.
• W2567889801 hasAuthorship W2567889801A5010584152 @default.
• W2567889801 hasAuthorship W2567889801A5018148458 @default.
• W2567889801 hasAuthorship W2567889801A5028019929 @default.
• W2567889801 hasAuthorship W2567889801A5034572004 @default.
• W2567889801 hasAuthorship W2567889801A5034900588 @default.
• W2567889801 hasAuthorship W2567889801A5036382416 @default.
• W2567889801 hasAuthorship W2567889801A5048694467 @default.
• W2567889801 hasAuthorship W2567889801A5051144449 @default.
• W2567889801 hasAuthorship W2567889801A5052417668 @default.
• W2567889801 hasAuthorship W2567889801A5068097109 @default.
• W2567889801 hasAuthorship W2567889801A5079045120 @default.
• W2567889801 hasBestOaLocation W25678898011 @default.
• W2567889801 hasConcept C121608353 @default.
• W2567889801 hasConcept C126322002 @default.
• W2567889801 hasConcept C143998085 @default.
• W2567889801 hasConcept C146357865 @default.
• W2567889801 hasConcept C151730666 @default.
• W2567889801 hasConcept C167135981 @default.
• W2567889801 hasConcept C188816634 @default.
• W2567889801 hasConcept C195910791 @default.
• W2567889801 hasConcept C2776256026 @default.
• W2567889801 hasConcept C50382708 @default.
• W2567889801 hasConcept C71924100 @default.
• W2567889801 hasConcept C72563966 @default.
• W2567889801 hasConcept C86803240 @default.
• W2567889801 hasConceptScore W2567889801C121608353 @default.
• W2567889801 hasConceptScore W2567889801C126322002 @default.
• W2567889801 hasConceptScore W2567889801C143998085 @default.
• W2567889801 hasConceptScore W2567889801C146357865 @default.
• W2567889801 hasConceptScore W2567889801C151730666 @default.
• W2567889801 hasConceptScore W2567889801C167135981 @default.
• W2567889801 hasConceptScore W2567889801C188816634 @default.
• W2567889801 hasConceptScore W2567889801C195910791 @default.
• W2567889801 hasConceptScore W2567889801C2776256026 @default.
• W2567889801 hasConceptScore W2567889801C50382708 @default.
• W2567889801 hasConceptScore W2567889801C71924100 @default.
• W2567889801 hasConceptScore W2567889801C72563966 @default.
• W2567889801 hasConceptScore W2567889801C86803240 @default.
• W2567889801 hasIssue "1" @default.
• W2567889801 hasLocation W25678898011 @default.
• W2567889801 hasOpenAccess W2567889801 @default.
• W2567889801 hasPrimaryLocation W25678898011 @default.
• W2567889801 hasRelatedWork W1971557041 @default.
• W2567889801 hasRelatedWork W2400217987 @default.
• W2567889801 hasRelatedWork W2769790736 @default.
• W2567889801 hasRelatedWork W2809998966 @default.
• W2567889801 hasRelatedWork W2889156515 @default.
• W2567889801 hasRelatedWork W3141511544 @default.
• W2567889801 hasRelatedWork W4231500275 @default.
• W2567889801 hasRelatedWork W4304808194 @default.
• W2567889801 hasRelatedWork W4311192294 @default.
• W2567889801 hasRelatedWork W4315778713 @default.
• W2567889801 hasVolume "12" @default.
• W2567889801 isParatext "false" @default.
• W2567889801 isRetracted "false" @default.
• W2567889801 magId "2567889801" @default.
• W2567889801 workType "article" @default.