Matches in SemOpenAlex for { <https://semopenalex.org/work/W2567990154> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2567990154 endingPage "S419" @default.
- W2567990154 startingPage "S419" @default.
- W2567990154 abstract "Our laboratory has demonstrated the augmented anti-tumor efficacy of intrapleurally administered cancer-antigen mesothelin (MSLN)-targeted chimeric antigen receptor (CAR) T cells (Sci Transl Med 2014), and translated the approach to a clinical trial (NCT02414269) for thoracic malignancies. We hypothesized that regionally administered MSLN CAR T cells can circulate systemically to achieve abscopal anti-tumor efficacy in an antigen-specific manner, and the abscopal efficacy can further be promoted by tumor-targeted radiation therapy (RT). Using optimized protocols that would permit non-necrotic, well-vascularized tumor growth in pleura, chest wall, peritoneum and flank, tumors were established in immunodeficient (NOD/SCID gamma) mice using mesothelioma or lung adenocarcinoma (LAC) cells. Tumor burden progression, MSLN-targeted CAR T-Cell accumulation at primary and distant tumors was monitored by noninvasive bioluminescence imaging (BLI) and tumor volume measurements. A single dose of MSLN CAR T cells administered intrapleurally proliferated (Figure 1A left panel), circulated extrapleurally and accumulated at abscopal sites, including the lymph nodes, chest wall, peritoneum, and flank within 3-5 days, with subsequent T-cell proliferation at abscopal sites (Figure 1A right panel). Primary tumor-targeted, single-dose, thoracic RT prior to T-cell administration augmented T-cell accumulation as demonstrated by BLI (Figure 1B) and tumor T-cell quantification (p<0.01). In a mouse model of primary pleural, abscopal antigen-expressing and non-expressing flank tumors (Figure 1C), a single, low-dose, non-cytotoxic thoracic RT enhanced abscopal site CAR T-cell accumulation that resulted in tumor regression (p=0.01; Figure 1D). Regionally administered mesothelin-targeted CAR T cells proliferate and eradicate the primary tumor, accumulate and demonstrate anti-tumor efficacy at abscopal sites prior to eradication of the primary tumor in an antigen-specific manner. A single low-dose primary tumor-targeted radiation therapy promotes scopal and abscopal anti-tumor efficacy. These results provide rationale to initiate a clinical trial of combination regional therapies with radiation therapy and CAR T cells." @default.
- W2567990154 created "2017-01-13" @default.
- W2567990154 creator A5004894465 @default.
- W2567990154 creator A5022990959 @default.
- W2567990154 creator A5023667267 @default.
- W2567990154 creator A5034626553 @default.
- W2567990154 creator A5052930984 @default.
- W2567990154 creator A5087032287 @default.
- W2567990154 date "2017-01-01" @default.
- W2567990154 modified "2023-10-13" @default.
- W2567990154 title "MA13.07 Tumor-Targeted Radiation Promotes Abscopal Efficacy of Regionally Administered CAR T Cells: A Rationale for Clinical Trial" @default.
- W2567990154 doi "https://doi.org/10.1016/j.jtho.2016.11.483" @default.
- W2567990154 hasPublicationYear "2017" @default.
- W2567990154 type Work @default.
- W2567990154 sameAs 2567990154 @default.
- W2567990154 citedByCount "2" @default.
- W2567990154 countsByYear W25679901542022 @default.
- W2567990154 countsByYear W25679901542023 @default.
- W2567990154 crossrefType "journal-article" @default.
- W2567990154 hasAuthorship W2567990154A5004894465 @default.
- W2567990154 hasAuthorship W2567990154A5022990959 @default.
- W2567990154 hasAuthorship W2567990154A5023667267 @default.
- W2567990154 hasAuthorship W2567990154A5034626553 @default.
- W2567990154 hasAuthorship W2567990154A5052930984 @default.
- W2567990154 hasAuthorship W2567990154A5087032287 @default.
- W2567990154 hasBestOaLocation W25679901541 @default.
- W2567990154 hasConcept C121608353 @default.
- W2567990154 hasConcept C126322002 @default.
- W2567990154 hasConcept C142724271 @default.
- W2567990154 hasConcept C147483822 @default.
- W2567990154 hasConcept C154317977 @default.
- W2567990154 hasConcept C202751555 @default.
- W2567990154 hasConcept C203014093 @default.
- W2567990154 hasConcept C2777045440 @default.
- W2567990154 hasConcept C2777407522 @default.
- W2567990154 hasConcept C2777701055 @default.
- W2567990154 hasConcept C2781274730 @default.
- W2567990154 hasConcept C502942594 @default.
- W2567990154 hasConcept C55493867 @default.
- W2567990154 hasConcept C71924100 @default.
- W2567990154 hasConcept C86803240 @default.
- W2567990154 hasConceptScore W2567990154C121608353 @default.
- W2567990154 hasConceptScore W2567990154C126322002 @default.
- W2567990154 hasConceptScore W2567990154C142724271 @default.
- W2567990154 hasConceptScore W2567990154C147483822 @default.
- W2567990154 hasConceptScore W2567990154C154317977 @default.
- W2567990154 hasConceptScore W2567990154C202751555 @default.
- W2567990154 hasConceptScore W2567990154C203014093 @default.
- W2567990154 hasConceptScore W2567990154C2777045440 @default.
- W2567990154 hasConceptScore W2567990154C2777407522 @default.
- W2567990154 hasConceptScore W2567990154C2777701055 @default.
- W2567990154 hasConceptScore W2567990154C2781274730 @default.
- W2567990154 hasConceptScore W2567990154C502942594 @default.
- W2567990154 hasConceptScore W2567990154C55493867 @default.
- W2567990154 hasConceptScore W2567990154C71924100 @default.
- W2567990154 hasConceptScore W2567990154C86803240 @default.
- W2567990154 hasIssue "1" @default.
- W2567990154 hasLocation W25679901541 @default.
- W2567990154 hasOpenAccess W2567990154 @default.
- W2567990154 hasPrimaryLocation W25679901541 @default.
- W2567990154 hasRelatedWork W1966714509 @default.
- W2567990154 hasRelatedWork W2002038251 @default.
- W2567990154 hasRelatedWork W2067695989 @default.
- W2567990154 hasRelatedWork W2074507660 @default.
- W2567990154 hasRelatedWork W2084135376 @default.
- W2567990154 hasRelatedWork W2156912849 @default.
- W2567990154 hasRelatedWork W2167410365 @default.
- W2567990154 hasRelatedWork W2170069434 @default.
- W2567990154 hasRelatedWork W2182366819 @default.
- W2567990154 hasRelatedWork W2465777043 @default.
- W2567990154 hasVolume "12" @default.
- W2567990154 isParatext "false" @default.
- W2567990154 isRetracted "false" @default.
- W2567990154 magId "2567990154" @default.
- W2567990154 workType "article" @default.