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• W2568009095 abstract "During therapeutic application, mesenchymal stem cells (MSCs) may interact with their environment via their expressed toll-like-receptors (TLRs) leading to pro- or anti-inflammatory immune responses. The present study aimed to describe the gingival margin-derived stem/progenitor cells' (G-MSCs) TLR-induced immune regulatory response to specific TLR agonists. Gingival cells were obtained, immunomagnetically sorted via anti-STRO-1 antibodies and seeded out to achieve colony forming units (CFUs). G-MSCs were investigated for stem cell characteristics and TLR expression. Specific TLR agonists were applied and m-RNA expression of pro- and anti-inflammatory factors was analyzed via real-time polymerase chain reaction. G-MSCs showed all characteristics of stem/progenitor cells. All TLR agonists induced pro-inflammatory cytokines, except for the TLR3 agonist, which significantly promoted the anti-inflammatory response. (p⩽0.05, Wilcoxon-Signed-Ranks-Test). TLR-induced immunomodulation by G-MSCs could impact their therapeutic potential in vivo. Two distinctive pro-inflammatory and an anti-inflammatory TLR-induced phenotypes of G-MSCs become noticeable in this study." @default.
• W2568009095 created "2017-01-13" @default.
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• W2568009095 date "2018-04-01" @default.
• W2568009095 modified "2023-10-01" @default.
• W2568009095 title "TLR-induced immunomodulatory cytokine expression by human gingival stem/progenitor cells" @default.
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• W2568009095 doi "https://doi.org/10.1016/j.cellimm.2017.01.007" @default.
• W2568009095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28093098" @default.
• W2568009095 hasPublicationYear "2018" @default.
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