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• W2568010916 abstract "MicroRNAs (miRNAs) are small non‑coding RNAs involved in an array of biological processes, and their dysregulation is associated with tumor development and progression. One such miRNA, miR‑219‑5p, is abnormally expressed in patients with colorectal cancer (CRC). In the present study, reverse transcription‑quantitative polymerase chain reaction was performed to measure miR‑219‑5p expression in cells from both CRC tumors, and surrounding healthy tissue. MTT and invasion assays were used to determine the role of miR‑219‑5p in regulating CRC cell proliferation and invasion, respectively. A luciferase assay was then performed to assess the binding of miR‑219‑5p to the CAPS gene that encodes calcyphosin protein. The present study confirmed that miR‑219‑5p expression is significantly downregulated in CRC tissue. miR‑219‑5p knockdown promoted the growth of HCT‑8 cells and increased the expression of calcyphosin protein (CAPS). On the other hand, overexpressing miR‑219‑5p inhibited HCT‑8 cell growth and invasion, and downregulated CAPS expression. In addition, CAPS was identified as the functional downstream target of miR‑219‑5p by directly targeting its 3'‑untranslated region. Therefore, miR‑219‑5p may function as a tumor suppressor by decreasing CAPS expression, and subsequently inhibit tumor proliferation and invasion. These results indicate that novel therapeutic strategies that increase miR‑219‑5p expression may be developed to treat CRC." @default.
• W2568010916 created "2017-01-13" @default.
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• W2568010916 date "2017-01-04" @default.
• W2568010916 modified "2023-09-28" @default.
• W2568010916 title "miR-219-5p suppresses the proliferation and invasion of colorectal cancer cells by targeting calcyphosin" @default.
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• W2568010916 doi "https://doi.org/10.3892/ol.2017.5570" @default.
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