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- W2568049773 abstract "Over the past several years remarkable therapeutic responses have been obtained with immunomodulatory monoclonal antibodies (mAbs), both in mice cite{10,18,20,48,54,61} and human cancer patients cite{1,3,14,28,30,39,80}. However, complete regressions and cures are infrequent and not predictable a nd some tumor types respond much worse than others. As an attempt to increase curability, we have investigated in mouse models the therapeutic efficacy of several mAb combinations, focusing on anti-PD-1/CTLA-4/CD137 and anti-PD-1/CTLA-4/CD137/CD19, and we have also combined mAbs with the chemotherapeutic drug cisplatin. Our data demonstrate an important contribution of anti-CD19 mAb to therapeutic efficacy, they show that intratumoral delivery of the mAbs is therapeutically more effective than systemic delivery, and that there is synergy when the mAbs are combined with cisplatin. In an attempt to improve predictability, we developed an in vitro model that may also be employed to search for novel immunomodulatory agents and combinations. This article reviews our data and discusses what is known about the underlying mechanisms." @default.
- W2568049773 created "2017-01-13" @default.
- W2568049773 creator A5000395798 @default.
- W2568049773 creator A5011338529 @default.
- W2568049773 creator A5059714974 @default.
- W2568049773 date "2017-04-24" @default.
- W2568049773 modified "2023-10-18" @default.
- W2568049773 title "Curing tumor-bearing mice by shifting a Th2 to a Th1 anti-tumor response" @default.
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- W2568049773 doi "https://doi.org/10.3233/hab-160309" @default.
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