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• W2568174977 startingPage "36" @default.
• W2568174977 abstract "Abstract Poly(vinyl alcohol) films are widely used in biomaterials applications due to their excellent chemical and thermal stability, transparency, biocompatibility, nontoxicity, and good film-forming ability. In this study, tetracycline hydrochloride (TC) has been encapsulated in quaternized chitosan nanoparticles (QChNPs) by ionic gelation of QCh with sodium tripolyphosphate (TPP). The success of the encapsulation was confirmed by Fourier transform infrared (FT-IR) spectroscopy. The obtained nanoparticles exhibited a regular distribution and spherical shape, with a size range of 450–800 nm as observed by scanning electron microscopy (SEM). The encapsulation efficiencies (EE) of the TC-loaded QChNPs were approximately 72–95%. The obtained nanoparticles were then added into a PVA solution to fabricate PVA films containing TC-loaded QChNPs. In vitro release studies showed an initial burst effect followed by a slow drug release. The antibacterial activities of the PVA films containing TC-loaded QChNPs against E. coli, S. Aureus , and Ent. faecium were evaluated systematically by the disk diffusion method (AATCC 147) and broth dilution method. Finally, the indirect cytotoxicity of the wound dressings was studied in mouse fibroblast (L929) and human fibroblast cells (FB cells) using an MTT assay." @default.
• W2568174977 created "2017-01-13" @default.
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• W2568174977 date "2017-04-01" @default.
• W2568174977 modified "2023-10-18" @default.
• W2568174977 title "Preparation, characterization and biocompatibility of poly(vinyl alcohol) films containing tetracycline hydrochloride-loaded quaternized chitosan nanoparticles" @default.
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• W2568174977 doi "https://doi.org/10.1016/j.jddst.2016.12.006" @default.
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