Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568273407> ?p ?o ?g. }
- W2568273407 endingPage "S23" @default.
- W2568273407 startingPage "S3" @default.
- W2568273407 abstract "Deterioration of cholesterol metabolism has recently been a frontier subject of investigation in the field of Alzheimer’s disease (AD). Though amyloid-β protein precursor (AβPP) primes the pathological cascade, changes in cholesterol levels and its intermediates, geranyl geranyl pyrophosphate and f arnesyl pyrophosphate, is expected to have a different consequence on AβPP processing and amyloid-β (Aβ) generation. However, the use of statins (HMG-COA reductase inhibitor) has been widely implicated in slowing down the pathogenic progression of AD, while the epidemiological reports on its biological effect remains controversial. Considering this fact, the choice of drug that could maintain cholesterol homeostasis without altering its biosynthesis may yield a better therapeutic efficacy on AD. Thus, the present study focused on determining the influence of cholesterol and isoprenoids on amyloidogenic-cleavage of AβPP, in addition to resveratrol as a potent therapeutic drug in CHO-APPswe cell lines. High levels of cholesterol were found to enhance the maturation of AβPP and altered the expression and subcellular localization of ADAM10, BACE1, and PS1 thereby promoting Aβ generation, whereas high isoprenoids increased both maturation as well as amyloidogenic-cleavage of AβPP, which was evident through β-CTF production. Interestingly, the therapeutic efficacy of resveratrol maintained cholesterol homeostasis and reduced the amyloidogenic burden through its ability to enhance SIRT1 expression and thereby regulating differential expression of AD determinants." @default.
- W2568273407 created "2017-01-13" @default.
- W2568273407 creator A5030109117 @default.
- W2568273407 creator A5056162077 @default.
- W2568273407 creator A5059204162 @default.
- W2568273407 creator A5060743498 @default.
- W2568273407 creator A5089087767 @default.
- W2568273407 creator A5090063659 @default.
- W2568273407 date "2017-09-15" @default.
- W2568273407 modified "2023-10-16" @default.
- W2568273407 title "Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer’s Disease" @default.
- W2568273407 cites W1490736749 @default.
- W2568273407 cites W1497372913 @default.
- W2568273407 cites W1589309926 @default.
- W2568273407 cites W1871783318 @default.
- W2568273407 cites W1962244211 @default.
- W2568273407 cites W1966697917 @default.
- W2568273407 cites W1969105333 @default.
- W2568273407 cites W1974790839 @default.
- W2568273407 cites W1982589658 @default.
- W2568273407 cites W1984964878 @default.
- W2568273407 cites W1990008286 @default.
- W2568273407 cites W1995350639 @default.
- W2568273407 cites W2005926152 @default.
- W2568273407 cites W2006386292 @default.
- W2568273407 cites W2006825244 @default.
- W2568273407 cites W2009111659 @default.
- W2568273407 cites W2013382634 @default.
- W2568273407 cites W2013926403 @default.
- W2568273407 cites W2027272551 @default.
- W2568273407 cites W2027308727 @default.
- W2568273407 cites W2029040938 @default.
- W2568273407 cites W2034545601 @default.
- W2568273407 cites W2037122545 @default.
- W2568273407 cites W2042449171 @default.
- W2568273407 cites W2042600422 @default.
- W2568273407 cites W2050341478 @default.
- W2568273407 cites W2054071408 @default.
- W2568273407 cites W2058205407 @default.
- W2568273407 cites W2068942754 @default.
- W2568273407 cites W2070138192 @default.
- W2568273407 cites W2070815033 @default.
- W2568273407 cites W2070868291 @default.
- W2568273407 cites W2090150925 @default.
- W2568273407 cites W2093586040 @default.
- W2568273407 cites W2096590285 @default.
- W2568273407 cites W2099556509 @default.
- W2568273407 cites W2101142595 @default.
- W2568273407 cites W2108292688 @default.
- W2568273407 cites W2119657643 @default.
- W2568273407 cites W2125121177 @default.
- W2568273407 cites W2133025814 @default.
- W2568273407 cites W2137644550 @default.
- W2568273407 cites W2146219284 @default.
- W2568273407 cites W2154587590 @default.
- W2568273407 cites W2155291455 @default.
- W2568273407 cites W2161678021 @default.
- W2568273407 cites W2165893887 @default.
- W2568273407 cites W2166069871 @default.
- W2568273407 cites W2169152986 @default.
- W2568273407 cites W2169555689 @default.
- W2568273407 cites W2171818152 @default.
- W2568273407 cites W2325685234 @default.
- W2568273407 cites W2343609596 @default.
- W2568273407 cites W2542578489 @default.
- W2568273407 cites W4233829850 @default.
- W2568273407 doi "https://doi.org/10.3233/jad-161034" @default.
- W2568273407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28059793" @default.
- W2568273407 hasPublicationYear "2017" @default.
- W2568273407 type Work @default.
- W2568273407 sameAs 2568273407 @default.
- W2568273407 citedByCount "27" @default.
- W2568273407 countsByYear W25682734072017 @default.
- W2568273407 countsByYear W25682734072018 @default.
- W2568273407 countsByYear W25682734072019 @default.
- W2568273407 countsByYear W25682734072020 @default.
- W2568273407 countsByYear W25682734072021 @default.
- W2568273407 countsByYear W25682734072022 @default.
- W2568273407 countsByYear W25682734072023 @default.
- W2568273407 crossrefType "journal-article" @default.
- W2568273407 hasAuthorship W2568273407A5030109117 @default.
- W2568273407 hasAuthorship W2568273407A5056162077 @default.
- W2568273407 hasAuthorship W2568273407A5059204162 @default.
- W2568273407 hasAuthorship W2568273407A5060743498 @default.
- W2568273407 hasAuthorship W2568273407A5089087767 @default.
- W2568273407 hasAuthorship W2568273407A5090063659 @default.
- W2568273407 hasConcept C104950815 @default.
- W2568273407 hasConcept C134651460 @default.
- W2568273407 hasConcept C181199279 @default.
- W2568273407 hasConcept C185592680 @default.
- W2568273407 hasConcept C2776816829 @default.
- W2568273407 hasConcept C2778163477 @default.
- W2568273407 hasConcept C2778259572 @default.
- W2568273407 hasConcept C2778715156 @default.
- W2568273407 hasConcept C2778827360 @default.
- W2568273407 hasConcept C55493867 @default.
- W2568273407 hasConcept C55728118 @default.
- W2568273407 hasConcept C86803240 @default.