Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568291192> ?p ?o ?g. }
- W2568291192 abstract "Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening pathogens due to its multi-drug resistance (MDR) and strong biofilm-forming capacity. Here, we described the screening of a novel chimeolysin (ClyF) that was active against planktonic and biofilm MRSA. Biochemical tests showed that ClyF was active against all S. aureus clinical isolates tested under planktonic and biofilm conditions. Structure analysis revealed that ClyF has an enhanced thermostability and pH tolerance than its parental lysin Pc by forming a hydrophobic cleft in the catalytic domain and an Ig-like structure in the cell-wall binding domain. A single intraperitoneally or topically administration of ClyF showed good MRSA removing efficacy in mouse models of bacteremia and burn wound infection, respectively. Our data collectively demonstrated that ClyF has good bactericidal activity against planktonic and biofilm MRSA both in vitro and in vivo, and therefore represents a useful antibacterial to combat MDR S. aureus." @default.
- W2568291192 created "2017-01-13" @default.
- W2568291192 creator A5013284854 @default.
- W2568291192 creator A5019819889 @default.
- W2568291192 creator A5020309893 @default.
- W2568291192 creator A5053621756 @default.
- W2568291192 creator A5090543024 @default.
- W2568291192 date "2017-01-09" @default.
- W2568291192 modified "2023-10-15" @default.
- W2568291192 title "A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus" @default.
- W2568291192 cites W1531926711 @default.
- W2568291192 cites W1584527715 @default.
- W2568291192 cites W1973349527 @default.
- W2568291192 cites W1977779489 @default.
- W2568291192 cites W1982452018 @default.
- W2568291192 cites W1985410473 @default.
- W2568291192 cites W1990768910 @default.
- W2568291192 cites W1991719306 @default.
- W2568291192 cites W1996430490 @default.
- W2568291192 cites W2009434802 @default.
- W2568291192 cites W2013598528 @default.
- W2568291192 cites W2034864076 @default.
- W2568291192 cites W2041529124 @default.
- W2568291192 cites W2048685592 @default.
- W2568291192 cites W2055823712 @default.
- W2568291192 cites W2056229483 @default.
- W2568291192 cites W2078550130 @default.
- W2568291192 cites W2081584806 @default.
- W2568291192 cites W2086910699 @default.
- W2568291192 cites W2098300761 @default.
- W2568291192 cites W2101937561 @default.
- W2568291192 cites W2109861005 @default.
- W2568291192 cites W2111893100 @default.
- W2568291192 cites W2116369083 @default.
- W2568291192 cites W2116914094 @default.
- W2568291192 cites W2118206090 @default.
- W2568291192 cites W2119500270 @default.
- W2568291192 cites W2121138643 @default.
- W2568291192 cites W2121457314 @default.
- W2568291192 cites W2122292306 @default.
- W2568291192 cites W2131773532 @default.
- W2568291192 cites W2133218818 @default.
- W2568291192 cites W2136215319 @default.
- W2568291192 cites W2141218426 @default.
- W2568291192 cites W2141365771 @default.
- W2568291192 cites W2144081223 @default.
- W2568291192 cites W2147574484 @default.
- W2568291192 cites W2148632765 @default.
- W2568291192 cites W2151630747 @default.
- W2568291192 cites W2151680163 @default.
- W2568291192 cites W2154066176 @default.
- W2568291192 cites W2154661271 @default.
- W2568291192 cites W2154714625 @default.
- W2568291192 cites W2158412800 @default.
- W2568291192 cites W2158831027 @default.
- W2568291192 cites W2161824581 @default.
- W2568291192 cites W2172074380 @default.
- W2568291192 cites W2172201188 @default.
- W2568291192 cites W2201713963 @default.
- W2568291192 cites W2228372403 @default.
- W2568291192 cites W2332533458 @default.
- W2568291192 cites W2345020184 @default.
- W2568291192 cites W2412267811 @default.
- W2568291192 cites W2413053666 @default.
- W2568291192 cites W2569299337 @default.
- W2568291192 doi "https://doi.org/10.1038/srep40182" @default.
- W2568291192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5220359" @default.
- W2568291192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28067286" @default.
- W2568291192 hasPublicationYear "2017" @default.
- W2568291192 type Work @default.
- W2568291192 sameAs 2568291192 @default.
- W2568291192 citedByCount "56" @default.
- W2568291192 countsByYear W25682911922017 @default.
- W2568291192 countsByYear W25682911922018 @default.
- W2568291192 countsByYear W25682911922019 @default.
- W2568291192 countsByYear W25682911922020 @default.
- W2568291192 countsByYear W25682911922021 @default.
- W2568291192 countsByYear W25682911922022 @default.
- W2568291192 countsByYear W25682911922023 @default.
- W2568291192 crossrefType "journal-article" @default.
- W2568291192 hasAuthorship W2568291192A5013284854 @default.
- W2568291192 hasAuthorship W2568291192A5019819889 @default.
- W2568291192 hasAuthorship W2568291192A5020309893 @default.
- W2568291192 hasAuthorship W2568291192A5053621756 @default.
- W2568291192 hasAuthorship W2568291192A5090543024 @default.
- W2568291192 hasBestOaLocation W25682911921 @default.
- W2568291192 hasConcept C104317684 @default.
- W2568291192 hasConcept C150903083 @default.
- W2568291192 hasConcept C181199279 @default.
- W2568291192 hasConcept C185592680 @default.
- W2568291192 hasConcept C207001950 @default.
- W2568291192 hasConcept C22538091 @default.
- W2568291192 hasConcept C2776441376 @default.
- W2568291192 hasConcept C2777052132 @default.
- W2568291192 hasConcept C2777334864 @default.
- W2568291192 hasConcept C2779489039 @default.
- W2568291192 hasConcept C2781216036 @default.
- W2568291192 hasConcept C523546767 @default.
- W2568291192 hasConcept C54355233 @default.
- W2568291192 hasConcept C547475151 @default.