FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568300053> ?p ?o ?g. }

• W2568300053 endingPage "2192" @default.
• W2568300053 startingPage "2182" @default.
• W2568300053 abstract "Chondrosarcoma, the second-most frequent primary bone malignancy, is generally more resistant to conventional chemotherapy and radiotherapy. Therefore, the development of an effective adjuvant therapy is necessary. Recently, targeting the epigenetic regulator such as bromodomain and extraterminal domain (BET) proteins has achieved great success. For instance, the bromodomain inhibitor JQ1 has been shown to inhibit the growth of several cancer cells both in vitro and in vivo. Herein, we demonstrated that JQ1 significantly inhibited chondrosarcoma cell growth and colony formation. JQ1 also induced marked G1-phase cell cycle arrest coincided with the up-regulation of p21WAF1/CIP1, p27Kip1, and Cyclin D1 expression, and the down-regulation of Cyclin E2 expression. Moreover, JQ1 induced the premature senescence of SW 1353 cells, and that prolong treatment of JQ1 caused cell apoptosis. Mechanistically, the JQ1-induced cell growth inhibition was correlated with the suppression of c-Myc and Bcl-xL, which are the prime genes for cell cycle control and anti-apoptosis. Furthermore, we demonstrated that p21 negatively regulated the expression of c-Myc and Bcl-xL upon JQ1 treatment, and that the growth inhibition of SW 1353 and Hs 819.T cells and induction of p21 were predominantly regulated by the LATS1/YAP signaling but not through a p53-dependent manner. In conclusion, we disclosed a novel mechanism that JQ1 inhibits cell proliferation, induces cell senescence and apoptosis of chondrosarcoma cells through the regulation of the YAP/p21/c-Myc/Bcl-xL signaling axis. J. Cell. Biochem. 118: 2182–2192, 2017. © 2017 Wiley Periodicals, Inc." @default.
• W2568300053 created "2017-01-13" @default.
• W2568300053 creator A5003430134 @default.
• W2568300053 creator A5007142517 @default.
• W2568300053 creator A5012921461 @default.
• W2568300053 creator A5016322200 @default.
• W2568300053 creator A5016555039 @default.
• W2568300053 creator A5020344633 @default.
• W2568300053 creator A5053605383 @default.
• W2568300053 creator A5081678526 @default.
• W2568300053 creator A5087820602 @default.
• W2568300053 date "2017-04-18" @default.
• W2568300053 modified "2023-10-18" @default.
• W2568300053 title "The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling" @default.
• W2568300053 cites W1518297150 @default.
• W2568300053 cites W1915617459 @default.
• W2568300053 cites W1966841369 @default.
• W2568300053 cites W1969182869 @default.
• W2568300053 cites W1973045105 @default.
• W2568300053 cites W1977662748 @default.
• W2568300053 cites W1992918548 @default.
• W2568300053 cites W2003872705 @default.
• W2568300053 cites W2009949436 @default.
• W2568300053 cites W2010669667 @default.
• W2568300053 cites W2012893548 @default.
• W2568300053 cites W2016326408 @default.
• W2568300053 cites W2031913409 @default.
• W2568300053 cites W2055215337 @default.
• W2568300053 cites W2069054327 @default.
• W2568300053 cites W2086168468 @default.
• W2568300053 cites W2092104789 @default.
• W2568300053 cites W2095424101 @default.
• W2568300053 cites W2108853871 @default.
• W2568300053 cites W2112541742 @default.
• W2568300053 cites W2129472307 @default.
• W2568300053 cites W2138582752 @default.
• W2568300053 cites W2146206637 @default.
• W2568300053 cites W2150954652 @default.
• W2568300053 cites W2155029478 @default.
• W2568300053 cites W2156496498 @default.
• W2568300053 cites W2157059360 @default.
• W2568300053 cites W2169896143 @default.
• W2568300053 cites W2180075246 @default.
• W2568300053 cites W2183089903 @default.
• W2568300053 cites W2207741310 @default.
• W2568300053 cites W2286870626 @default.
• W2568300053 cites W2339920561 @default.
• W2568300053 cites W2344198014 @default.
• W2568300053 cites W2390782195 @default.
• W2568300053 doi "https://doi.org/10.1002/jcb.25863" @default.
• W2568300053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28059436" @default.
• W2568300053 hasPublicationYear "2017" @default.
• W2568300053 type Work @default.
• W2568300053 sameAs 2568300053 @default.
• W2568300053 citedByCount "42" @default.
• W2568300053 countsByYear W25683000532017 @default.
• W2568300053 countsByYear W25683000532018 @default.
• W2568300053 countsByYear W25683000532019 @default.
• W2568300053 countsByYear W25683000532020 @default.
• W2568300053 countsByYear W25683000532021 @default.
• W2568300053 countsByYear W25683000532022 @default.
• W2568300053 countsByYear W25683000532023 @default.
• W2568300053 crossrefType "journal-article" @default.
• W2568300053 hasAuthorship W2568300053A5003430134 @default.
• W2568300053 hasAuthorship W2568300053A5007142517 @default.
• W2568300053 hasAuthorship W2568300053A5012921461 @default.
• W2568300053 hasAuthorship W2568300053A5016322200 @default.
• W2568300053 hasAuthorship W2568300053A5016555039 @default.
• W2568300053 hasAuthorship W2568300053A5020344633 @default.
• W2568300053 hasAuthorship W2568300053A5053605383 @default.
• W2568300053 hasAuthorship W2568300053A5081678526 @default.
• W2568300053 hasAuthorship W2568300053A5087820602 @default.
• W2568300053 hasConcept C104317684 @default.
• W2568300053 hasConcept C105696609 @default.
• W2568300053 hasConcept C120504264 @default.
• W2568300053 hasConcept C16438837 @default.
• W2568300053 hasConcept C185592680 @default.
• W2568300053 hasConcept C190283241 @default.
• W2568300053 hasConcept C199835354 @default.
• W2568300053 hasConcept C2778437423 @default.
• W2568300053 hasConcept C29537977 @default.
• W2568300053 hasConcept C41091548 @default.
• W2568300053 hasConcept C502942594 @default.
• W2568300053 hasConcept C55493867 @default.
• W2568300053 hasConcept C62112901 @default.
• W2568300053 hasConcept C74401373 @default.
• W2568300053 hasConcept C86803240 @default.
• W2568300053 hasConcept C94561458 @default.
• W2568300053 hasConcept C95444343 @default.
• W2568300053 hasConcept C9743823 @default.
• W2568300053 hasConceptScore W2568300053C104317684 @default.
• W2568300053 hasConceptScore W2568300053C105696609 @default.
• W2568300053 hasConceptScore W2568300053C120504264 @default.
• W2568300053 hasConceptScore W2568300053C16438837 @default.
• W2568300053 hasConceptScore W2568300053C185592680 @default.
• W2568300053 hasConceptScore W2568300053C190283241 @default.
• W2568300053 hasConceptScore W2568300053C199835354 @default.
• W2568300053 hasConceptScore W2568300053C2778437423 @default.

• next