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- W2568397404 abstract "Toxoplasma gondii, a ubiquitous intracellular parasite, has a strong tropism for the brain tissue, where it forms intracellular cysts within the neurons and glial cells, establishing a chronic infection. Although latent toxoplasmosis is generally assumed to be asymptomatic in immunocompetent individuals, it is now clear that it can induce behavioral manipulations in mice and infected humans. Moreover, a strong relation has emerged in recent years between toxoplasmosis and psychiatric disorders. The link between T. gondii and schizophrenia has been the most widely documented; however, a significant association with bipolar disorder (BD) and suicidal/aggressive behaviors has also been detected. T. gondii may play a role in the etiopathogenesis of psychiatric disorders affecting neurotransmitters, especially dopamine, that are implicated in the emergence of psychosis and behavioral Toxoplasma-induced abnormalities, and inducing brain inflammation by the direct stimulation of inflammatory cytokines in the central nervous system. Besides this, there is increasing evidence for a prominent role of immune dysregulation in psychosis and BD. The aim of this review is to describe recent evidence suggesting a link between Toxoplasma gondii and BD, focusing on the interaction between immune responses and this infectious agent in the etiopathogenesis of psychiatric symptoms." @default.
- W2568397404 created "2017-01-13" @default.
- W2568397404 creator A5029935476 @default.
- W2568397404 creator A5042946289 @default.
- W2568397404 creator A5048638967 @default.
- W2568397404 creator A5054171803 @default.
- W2568397404 creator A5061195758 @default.
- W2568397404 date "2017-01-10" @default.
- W2568397404 modified "2023-10-17" @default.
- W2568397404 title "Is Toxoplasma gondii a Trigger of Bipolar Disorder?" @default.
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