FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568502415> ?p ?o ?g. }

• W2568502415 endingPage "3653" @default.
• W2568502415 startingPage "3643" @default.
• W2568502415 abstract "Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is involved in the development and progression of many types of tumors. An aberrant expression of MALAT1 was observed in many kinds of cancers. However, the exact effects and molecular mechanisms of MALAT1 in human hilar cholangiocarcinoma (HCCA) progression are still unknown. Here, we investigated the role of MALAT1 in human HCCA cell lines and clinical tumor samples in order to determine the function of this lncRNA. In our research, lncRNA-MALAT1 was specifically upregulated in HCCA tissues and cell lines, and was associated with pathological T stage, a larger tumor size, and perineural invasion. Knockdown of MALAT1 inhibited the proliferation, migration, and invasion of human HCCA cell. In addition, chemokine receptor-4 (CXCR4) was involved in MALAT1 induced human HCCA growth, migration, and invasion. By using online tools and a series of mechanistic analysis, we also demonstrated that miR-204-dependent CXCR4 regulation was required in MALAT1 modulating HCCA cell growth, migration and invasion. Taken together, our data indicated that MALAT1 might play an oncogenic role in HCCA through miR-204-dependent CXCR4 regulation, and could be regarded as a therapeutic target in HCCA. J. Cell. Biochem. 118: 3643-3653, 2017. © 2017 Wiley Periodicals, Inc." @default.
• W2568502415 created "2017-01-13" @default.
• W2568502415 creator A5012402220 @default.
• W2568502415 creator A5023214008 @default.
• W2568502415 creator A5046951299 @default.
• W2568502415 date "2017-07-11" @default.
• W2568502415 modified "2023-10-18" @default.
• W2568502415 title "Long Non‐Coding RNA MALAT1 Interacts With miR‐204 to Modulate Human Hilar Cholangiocarcinoma Proliferation, Migration, and Invasion by Targeting CXCR4" @default.
• W2568502415 cites W1192215044 @default.
• W2568502415 cites W1511246213 @default.
• W2568502415 cites W1839280722 @default.
• W2568502415 cites W1857021700 @default.
• W2568502415 cites W1862251752 @default.
• W2568502415 cites W1867767808 @default.
• W2568502415 cites W1956510785 @default.
• W2568502415 cites W1985359974 @default.
• W2568502415 cites W1989057528 @default.
• W2568502415 cites W1990895545 @default.
• W2568502415 cites W2018005623 @default.
• W2568502415 cites W2041735615 @default.
• W2568502415 cites W2055700498 @default.
• W2568502415 cites W2065504822 @default.
• W2568502415 cites W2082268152 @default.
• W2568502415 cites W2091161969 @default.
• W2568502415 cites W2102978602 @default.
• W2568502415 cites W2104363560 @default.
• W2568502415 cites W2111180389 @default.
• W2568502415 cites W2111356196 @default.
• W2568502415 cites W2139882963 @default.
• W2568502415 cites W2145931730 @default.
• W2568502415 cites W2147287621 @default.
• W2568502415 cites W2147383099 @default.
• W2568502415 cites W2149211024 @default.
• W2568502415 cites W2152002064 @default.
• W2568502415 cites W2166810745 @default.
• W2568502415 cites W2213926016 @default.
• W2568502415 cites W2278011143 @default.
• W2568502415 cites W2278129493 @default.
• W2568502415 cites W2317281638 @default.
• W2568502415 cites W2340743383 @default.
• W2568502415 cites W2340837699 @default.
• W2568502415 cites W2361558676 @default.
• W2568502415 cites W2373555242 @default.
• W2568502415 cites W2486152093 @default.
• W2568502415 cites W2499419268 @default.
• W2568502415 cites W2509326345 @default.
• W2568502415 cites W4239222438 @default.
• W2568502415 cites W841437724 @default.
• W2568502415 doi "https://doi.org/10.1002/jcb.25862" @default.
• W2568502415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28059437" @default.
• W2568502415 hasPublicationYear "2017" @default.
• W2568502415 type Work @default.
• W2568502415 sameAs 2568502415 @default.
• W2568502415 citedByCount "62" @default.
• W2568502415 countsByYear W25685024152017 @default.
• W2568502415 countsByYear W25685024152018 @default.
• W2568502415 countsByYear W25685024152019 @default.
• W2568502415 countsByYear W25685024152020 @default.
• W2568502415 countsByYear W25685024152021 @default.
• W2568502415 countsByYear W25685024152022 @default.
• W2568502415 countsByYear W25685024152023 @default.
• W2568502415 crossrefType "journal-article" @default.
• W2568502415 hasAuthorship W2568502415A5012402220 @default.
• W2568502415 hasAuthorship W2568502415A5023214008 @default.
• W2568502415 hasAuthorship W2568502415A5046951299 @default.
• W2568502415 hasConcept C104317684 @default.
• W2568502415 hasConcept C121608353 @default.
• W2568502415 hasConcept C127561419 @default.
• W2568502415 hasConcept C129470790 @default.
• W2568502415 hasConcept C13373296 @default.
• W2568502415 hasConcept C137738243 @default.
• W2568502415 hasConcept C1491633281 @default.
• W2568502415 hasConcept C170493617 @default.
• W2568502415 hasConcept C173396325 @default.
• W2568502415 hasConcept C2779013556 @default.
• W2568502415 hasConcept C2779134362 @default.
• W2568502415 hasConcept C2781182431 @default.
• W2568502415 hasConcept C502942594 @default.
• W2568502415 hasConcept C54355233 @default.
• W2568502415 hasConcept C62112901 @default.
• W2568502415 hasConcept C62203573 @default.
• W2568502415 hasConcept C81885089 @default.
• W2568502415 hasConcept C86803240 @default.
• W2568502415 hasConceptScore W2568502415C104317684 @default.
• W2568502415 hasConceptScore W2568502415C121608353 @default.
• W2568502415 hasConceptScore W2568502415C127561419 @default.
• W2568502415 hasConceptScore W2568502415C129470790 @default.
• W2568502415 hasConceptScore W2568502415C13373296 @default.
• W2568502415 hasConceptScore W2568502415C137738243 @default.
• W2568502415 hasConceptScore W2568502415C1491633281 @default.
• W2568502415 hasConceptScore W2568502415C170493617 @default.
• W2568502415 hasConceptScore W2568502415C173396325 @default.
• W2568502415 hasConceptScore W2568502415C2779013556 @default.
• W2568502415 hasConceptScore W2568502415C2779134362 @default.
• W2568502415 hasConceptScore W2568502415C2781182431 @default.
• W2568502415 hasConceptScore W2568502415C502942594 @default.
• W2568502415 hasConceptScore W2568502415C54355233 @default.
• W2568502415 hasConceptScore W2568502415C62112901 @default.

• next