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- W2568597107 abstract "Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, whereas mitochondrial dysfunction plays a vital role in the genesis of diabetic cardiomyopathy. Metabolic regulation targeting mitochondrial dysfunction is expected to be a reasonable strategy for treating diabetic cardiomyopathy. Peroxisome proliferator-activated receptors (PPARs) are master executors in regulating glucose and lipid homeostasis and also modulate mitochondrial function. However, synthetic PPAR agonists used for treating hyperlipidemia and DM have shown controversial effects on cardiovascular regulation. This article reviews our updated understanding of the beneficial and detrimental effects of PPARs on mitochondria in diabetic hearts." @default.
- W2568597107 created "2017-01-13" @default.
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- W2568597107 date "2017-01-10" @default.
- W2568597107 modified "2023-10-17" @default.
- W2568597107 title "PPARs modulate cardiac metabolism and mitochondrial function in diabetes" @default.
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- W2568597107 doi "https://doi.org/10.1186/s12929-016-0309-5" @default.
- W2568597107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5223385" @default.
- W2568597107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28069019" @default.
- W2568597107 hasPublicationYear "2017" @default.
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