FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568666126> ?p ?o ?g. }

• W2568666126 endingPage "57" @default.
• W2568666126 startingPage "49" @default.
• W2568666126 abstract "Atherosclerosis attracts increasing global attention because of its morbidity and mortality. G004, as a synthetic sulfonylurea compound, has been confirmed to have anti-hyperglycaemia, anti-platelet and anti-thrombus effects. The aim of the present study was to investigate whether G004 suppress the onset and development of atherosclerosis and illuminate its probable mechanism of action. ApoE-/- mice that were fed a high-fat diet were randomly divided into five groups by weight; subsequently, they were treated with vehicle, G004, at different doses or atorvastatin once daily for 12weeks. Meanwhile, C57BL/6 mice with the same diet served as the normal controls. Then, the serum lipid profiles and histopathological damage to the liver, kidney, aortic arch and aortic root were analysed. The activation of endothelial nitric oxide synthase (eNOS) and levels of inflammatory markers were detected. Reverse cholesterol transport (RCT) was assessed in vivo by intraperitoneal injection of RAW264.7 cells that were radiolabelled with 3H-cholesterol. The results indicated that G004 ameliorated the serum lipid accumulation, atherosclerotic lesions and liver steatosis. Additionally, this compound increased the expression of SIRT1 and eNOS as well as the phosphorylation and deacetylation of eNOS in the aorta, alleviating the inflammatory state. RCT was promoted in ApoE-/- mice, which was accompanied by increased expression of SIRT1/LXRα/ABCA1/G1 in the liver, and similar results appeared in the cholesterol efflux assay in RAW264.7 cells. The results provide a strong rationale for G004 to be an efficient anti-atherosclerosis agent that improved vascular endothelial dysfunction by stimulating SIRT1/eNOS and promoted RCT by stimulating SIRT1/LXRα/ABCA1/G1." @default.
• W2568666126 created "2017-01-13" @default.
• W2568666126 creator A5015594501 @default.
• W2568666126 creator A5026552070 @default.
• W2568666126 creator A5049506049 @default.
• W2568666126 creator A5074915453 @default.
• W2568666126 creator A5081564461 @default.
• W2568666126 creator A5085593058 @default.
• W2568666126 creator A5090372525 @default.
• W2568666126 creator A5063672280 @default.
• W2568666126 date "2017-02-01" @default.
• W2568666126 modified "2023-09-26" @default.
• W2568666126 title "G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE −/− mice" @default.
• W2568666126 cites W1515725948 @default.
• W2568666126 cites W1580652849 @default.
• W2568666126 cites W16027210 @default.
• W2568666126 cites W1965711049 @default.
• W2568666126 cites W1970516435 @default.
• W2568666126 cites W1974702385 @default.
• W2568666126 cites W1975233675 @default.
• W2568666126 cites W1978056185 @default.
• W2568666126 cites W1982594212 @default.
• W2568666126 cites W1984428730 @default.
• W2568666126 cites W1995188356 @default.
• W2568666126 cites W2003882200 @default.
• W2568666126 cites W2010496144 @default.
• W2568666126 cites W2010978375 @default.
• W2568666126 cites W2017037853 @default.
• W2568666126 cites W2018239666 @default.
• W2568666126 cites W2024605581 @default.
• W2568666126 cites W2025165872 @default.
• W2568666126 cites W2033896075 @default.
• W2568666126 cites W2036700466 @default.
• W2568666126 cites W2044463095 @default.
• W2568666126 cites W2062403586 @default.
• W2568666126 cites W2066411558 @default.
• W2568666126 cites W2074970705 @default.
• W2568666126 cites W2075983335 @default.
• W2568666126 cites W2082749730 @default.
• W2568666126 cites W2086025811 @default.
• W2568666126 cites W2087582854 @default.
• W2568666126 cites W2088503595 @default.
• W2568666126 cites W2093244608 @default.
• W2568666126 cites W2093624684 @default.
• W2568666126 cites W2103853094 @default.
• W2568666126 cites W2110926368 @default.
• W2568666126 cites W2111904970 @default.
• W2568666126 cites W2112079166 @default.
• W2568666126 cites W2117901133 @default.
• W2568666126 cites W2118272405 @default.
• W2568666126 cites W2121141378 @default.
• W2568666126 cites W2123043503 @default.
• W2568666126 cites W2127393713 @default.
• W2568666126 cites W2130950159 @default.
• W2568666126 cites W2156118702 @default.
• W2568666126 cites W2162405407 @default.
• W2568666126 cites W2417490015 @default.
• W2568666126 cites W244605186 @default.
• W2568666126 cites W2917462181 @default.
• W2568666126 cites W4292172722 @default.
• W2568666126 doi "https://doi.org/10.1016/j.vph.2016.12.003" @default.
• W2568666126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28069546" @default.
• W2568666126 hasPublicationYear "2017" @default.
• W2568666126 type Work @default.
• W2568666126 sameAs 2568666126 @default.
• W2568666126 citedByCount "11" @default.
• W2568666126 countsByYear W25686661262018 @default.
• W2568666126 countsByYear W25686661262019 @default.
• W2568666126 countsByYear W25686661262020 @default.
• W2568666126 countsByYear W25686661262021 @default.
• W2568666126 countsByYear W25686661262022 @default.
• W2568666126 countsByYear W25686661262023 @default.
• W2568666126 crossrefType "journal-article" @default.
• W2568666126 hasAuthorship W2568666126A5015594501 @default.
• W2568666126 hasAuthorship W2568666126A5026552070 @default.
• W2568666126 hasAuthorship W2568666126A5049506049 @default.
• W2568666126 hasAuthorship W2568666126A5063672280 @default.
• W2568666126 hasAuthorship W2568666126A5074915453 @default.
• W2568666126 hasAuthorship W2568666126A5081564461 @default.
• W2568666126 hasAuthorship W2568666126A5085593058 @default.
• W2568666126 hasAuthorship W2568666126A5090372525 @default.
• W2568666126 hasConcept C104317684 @default.
• W2568666126 hasConcept C126322002 @default.
• W2568666126 hasConcept C134018914 @default.
• W2568666126 hasConcept C149011108 @default.
• W2568666126 hasConcept C185592680 @default.
• W2568666126 hasConcept C2776175330 @default.
• W2568666126 hasConcept C2777622882 @default.
• W2568666126 hasConcept C2777704780 @default.
• W2568666126 hasConcept C2778163477 @default.
• W2568666126 hasConcept C2778326061 @default.
• W2568666126 hasConcept C2779134260 @default.
• W2568666126 hasConcept C2780159080 @default.
• W2568666126 hasConcept C2780323712 @default.
• W2568666126 hasConcept C2780972559 @default.
• W2568666126 hasConcept C519581460 @default.
• W2568666126 hasConcept C55493867 @default.
• W2568666126 hasConcept C555293320 @default.

• next